Stability of proteins in aqueous solution and solid state

S. Jacob, A. Shirwaikar, K. Srinivasan, A. Joseph, S. Prabu, R. Mahalaxmi, R. Kumar

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22 Citations (Scopus)

Abstract

In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.
Original languageEnglish
Pages (from-to)154-163
Number of pages10
JournalIndian Journal of Pharmaceutical Sciences
Volume68
Issue number2
Publication statusPublished - 2006

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Jacob, S., Shirwaikar, A., Srinivasan, K., Joseph, A., Prabu, S., Mahalaxmi, R., & Kumar, R. (2006). Stability of proteins in aqueous solution and solid state. Indian Journal of Pharmaceutical Sciences, 68(2), 154-163.