Stability of proteins in aqueous solution and solid state

S. Jacob, A. Shirwaikar, K. Srinivasan, A. Joseph, S. Prabu, R. Mahalaxmi, R. Kumar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.
Original languageEnglish
Pages (from-to)154-163
Number of pages10
JournalIndian Journal of Pharmaceutical Sciences
Volume68
Issue number2
Publication statusPublished - 2006

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Protein Stability
Pharmaceutical Preparations
Proteins
Peptides
Therapeutics

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Jacob, S., Shirwaikar, A., Srinivasan, K., Joseph, A., Prabu, S., Mahalaxmi, R., & Kumar, R. (2006). Stability of proteins in aqueous solution and solid state. Indian Journal of Pharmaceutical Sciences, 68(2), 154-163.
Jacob, S. ; Shirwaikar, A. ; Srinivasan, K. ; Joseph, A. ; Prabu, S. ; Mahalaxmi, R. ; Kumar, R. / Stability of proteins in aqueous solution and solid state. In: Indian Journal of Pharmaceutical Sciences. 2006 ; Vol. 68, No. 2. pp. 154-163.
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title = "Stability of proteins in aqueous solution and solid state",
abstract = "In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.",
author = "S. Jacob and A. Shirwaikar and K. Srinivasan and A. Joseph and S. Prabu and R. Mahalaxmi and R. Kumar",
note = "Cited By :16 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHEIndia; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: protein, 67254-75-5 References: Sislbart, L.K., Karen, D.F., (1989) Science, 243, p. 1462; Pan, Y., Li, Y., Zhao, H., Zheng, J., Xu, Wei, G., Hao, J., Cui, F., (2002) Int. J. Pharm., 249, p. 139; Fattal, E., Pecquet, S., Couvreur, P., Andremont, A., (2002) Int. J. Pharm., 242, p. 15; Reddy, T., Tammishetti, S., (2002) J. Microencapsul., 19, p. 311; Eiamtrakarn, S., Itoh, Y., Kishimoto, J., Yoshikawa, Y., Shibata, N., Murakami, M., Takada, K., (2002) Biomaterials, 23, p. 145; Zheng, J.Y., Fulu, M.Y., Lee, D.Y., Barber, T.E., Adjei, A.L., (2001) Pharm.Dev. Technol., 6, p. 521; Gautam, S., Barna, B., Chiang, T., Pettay, J., Deodhar, S., (1987) J. Biol. Response Mod., 6, p. 346; Reddy, R.K., Banga, A.K., (1993) Pharm. Times, 59, p. 92; Manning, M.C., Patel, K., Borchardt, R.T., (1989) Pharm. Res., 6, pp. 903-918; Goolcharran, C., Khossravi, M., Borchardt, R.T., (2000) Pharmaceutical Formulation and Development of Peptides and Proteins, p. 70. , Frokjaer, S. and Hovgaards, L. Eds., Taylor and Francis, London; Brange, J., (2000) Pharmaceutical Formulation and Development of Proteins and Peptides, p. 89. , Frokjaer, S. and Hovgaards, L Eds., Taylor and Francis, London; Volkin, D.B., Middaugh, C.R., (1992) Stability of Protein Pharmaceuticals Part A: Chemical and Physical Pathways of Protein Degradation, p. 215. , Ahern, T.J. and Mannings, M.C Eds., Plenum Press, New York; Manning, M.C., Patel, Borchardt, R.T., (1989) Pharm. Res., 6, p. 903; Brange, J., (2000) Pharmaceutical Formulation and Development of Proteins and Peptides, p. 89. , Frokjaer, S. and Hovgaards, L Eds., Taylor and Francis, London; Volkin, D.B., Middaugh, C.R., (1992) Stability of Protein Pharmaceuticals Part A: Chemical and Physical Pathways of Protein Degradation, p. 216. , Ahern, T.J. and Manning, M.C Eds., Plenum Press, New York; Randolph, T.W., Sjones, L., (2002) Rational Design of Stable Protein Formulations, Theory and Practice, p. 198. , Carpenter,J.F. and Mannings,M.C. Eds., Kluwert Academic /Plenum Publishers, New York; Labuza, T.P., Saltmarch, M., (1981) Water Activity: Influence on Food Quality, p. 605. , Rockland, L.B.and Stewart, G.F.Eds., Academic Press, NewYork; Li, S., Patapoff, T.W., Overcashier, D., Hsu, C., Nguyen, T.H., Borchardt, R.T., (1996) J. Pharm. Sci., 85, p. 873; Schwendeman, S.P., Castantino, H.R., Gupta, R.K., Siber, G.R., Klibanov, A.M., Langer, R., (1995) Proc. Natl. Acad. 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year = "2006",
language = "English",
volume = "68",
pages = "154--163",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "2",

}

Jacob, S, Shirwaikar, A, Srinivasan, K, Joseph, A, Prabu, S, Mahalaxmi, R & Kumar, R 2006, 'Stability of proteins in aqueous solution and solid state', Indian Journal of Pharmaceutical Sciences, vol. 68, no. 2, pp. 154-163.

Stability of proteins in aqueous solution and solid state. / Jacob, S.; Shirwaikar, A.; Srinivasan, K.; Joseph, A.; Prabu, S.; Mahalaxmi, R.; Kumar, R.

In: Indian Journal of Pharmaceutical Sciences, Vol. 68, No. 2, 2006, p. 154-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stability of proteins in aqueous solution and solid state

AU - Jacob, S.

AU - Shirwaikar, A.

AU - Srinivasan, K.

AU - Joseph, A.

AU - Prabu, S.

AU - Mahalaxmi, R.

AU - Kumar, R.

N1 - Cited By :16 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHEIndia; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: protein, 67254-75-5 References: Sislbart, L.K., Karen, D.F., (1989) Science, 243, p. 1462; Pan, Y., Li, Y., Zhao, H., Zheng, J., Xu, Wei, G., Hao, J., Cui, F., (2002) Int. J. Pharm., 249, p. 139; Fattal, E., Pecquet, S., Couvreur, P., Andremont, A., (2002) Int. J. Pharm., 242, p. 15; Reddy, T., Tammishetti, S., (2002) J. Microencapsul., 19, p. 311; Eiamtrakarn, S., Itoh, Y., Kishimoto, J., Yoshikawa, Y., Shibata, N., Murakami, M., Takada, K., (2002) Biomaterials, 23, p. 145; Zheng, J.Y., Fulu, M.Y., Lee, D.Y., Barber, T.E., Adjei, A.L., (2001) Pharm.Dev. Technol., 6, p. 521; Gautam, S., Barna, B., Chiang, T., Pettay, J., Deodhar, S., (1987) J. Biol. Response Mod., 6, p. 346; Reddy, R.K., Banga, A.K., (1993) Pharm. Times, 59, p. 92; Manning, M.C., Patel, K., Borchardt, R.T., (1989) Pharm. Res., 6, pp. 903-918; Goolcharran, C., Khossravi, M., Borchardt, R.T., (2000) Pharmaceutical Formulation and Development of Peptides and Proteins, p. 70. , Frokjaer, S. and Hovgaards, L. Eds., Taylor and Francis, London; Brange, J., (2000) Pharmaceutical Formulation and Development of Proteins and Peptides, p. 89. , Frokjaer, S. and Hovgaards, L Eds., Taylor and Francis, London; Volkin, D.B., Middaugh, C.R., (1992) Stability of Protein Pharmaceuticals Part A: Chemical and Physical Pathways of Protein Degradation, p. 215. , Ahern, T.J. and Mannings, M.C Eds., Plenum Press, New York; Manning, M.C., Patel, Borchardt, R.T., (1989) Pharm. Res., 6, p. 903; Brange, J., (2000) Pharmaceutical Formulation and Development of Proteins and Peptides, p. 89. , Frokjaer, S. and Hovgaards, L Eds., Taylor and Francis, London; Volkin, D.B., Middaugh, C.R., (1992) Stability of Protein Pharmaceuticals Part A: Chemical and Physical Pathways of Protein Degradation, p. 216. , Ahern, T.J. and Manning, M.C Eds., Plenum Press, New York; Randolph, T.W., Sjones, L., (2002) Rational Design of Stable Protein Formulations, Theory and Practice, p. 198. , Carpenter,J.F. and Mannings,M.C. Eds., Kluwert Academic /Plenum Publishers, New York; Labuza, T.P., Saltmarch, M., (1981) Water Activity: Influence on Food Quality, p. 605. , Rockland, L.B.and Stewart, G.F.Eds., Academic Press, NewYork; Li, S., Patapoff, T.W., Overcashier, D., Hsu, C., Nguyen, T.H., Borchardt, R.T., (1996) J. Pharm. Sci., 85, p. 873; Schwendeman, S.P., Castantino, H.R., Gupta, R.K., Siber, G.R., Klibanov, A.M., Langer, R., (1995) Proc. Natl. Acad. 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PY - 2006

Y1 - 2006

N2 - In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.

AB - In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.

M3 - Article

VL - 68

SP - 154

EP - 163

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 2

ER -