Staphylococcus aureus bacteremia in an Indian tertiary care hospital: Observational study on clinical epidemiology, resistance characteristics, and carriage of the Panton-Valentine leukocidin gene

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Abstract

Objectives: To analyze the epidemiology and laboratory characteristics of Staphylococcus aureus bacteremia (SAB) in an Indian tertiary care hospital. Methods: We collected clinical, epidemiological, and laboratory data of all cases of SAB during August 2010 through July 2011. All isolates were tested for the Panton-Valentine leukocidin (PVL) gene. Results: Eighteen percent of all blood stream infections (BSIs) were attributable to S. aureus. Among a total of 70 cases of SAB, 54% were due to methicillin-resistant S. aureus (MRSA) and 46% to methicillin-susceptible S. aureus (MSSA). Seventy-four percent of the cases had community-acquired (CA) SAB, among whom 69% had been hospitalized previously. Skin and soft tissue infections (SSTI) (30%) and respiratory infections (24%) were the common sources of bacteremia. The overall case fatality rate was 27%, and a similar percentage (23%) of patients discontinued therapy due to a poor medical outcome. The PVL gene was detected in 16% of S. aureus isolates, predominantly in CA-. S. aureus (82%). SSTIs and pneumonia were the common sources of bacteremia in 45% of patients infected with a PVL-positive strain. Conclusions: S. aureus is a significant cause of BSI with a case fatality rate comparable to those of other developing nations. The upsurge in MRSA rates is alarming in our setup. Antibiotic stewardship and strict control of antibiotic use must be implemented by health care professionals to curb the increasing trend in MRSA BSIs.

Original languageEnglish
Pages (from-to)1051-1055
Number of pages5
JournalInternational Journal of Infectious Diseases
Volume17
Issue number11
DOIs
Publication statusPublished - 11-2013

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Tertiary Healthcare
Bacteremia
Tertiary Care Centers
Observational Studies
Staphylococcus aureus
Epidemiology
Genes
Methicillin-Resistant Staphylococcus aureus
Infection
Anti-Bacterial Agents
Panton-Valentine leukocidin
Soft Tissue Infections
Methicillin
Mortality
Respiratory Tract Infections
Developing Countries
Pneumonia
Delivery of Health Care
Skin

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{e397639958294b6fb2516a70128dc8ea,
title = "Staphylococcus aureus bacteremia in an Indian tertiary care hospital: Observational study on clinical epidemiology, resistance characteristics, and carriage of the Panton-Valentine leukocidin gene",
abstract = "Objectives: To analyze the epidemiology and laboratory characteristics of Staphylococcus aureus bacteremia (SAB) in an Indian tertiary care hospital. Methods: We collected clinical, epidemiological, and laboratory data of all cases of SAB during August 2010 through July 2011. All isolates were tested for the Panton-Valentine leukocidin (PVL) gene. Results: Eighteen percent of all blood stream infections (BSIs) were attributable to S. aureus. Among a total of 70 cases of SAB, 54{\%} were due to methicillin-resistant S. aureus (MRSA) and 46{\%} to methicillin-susceptible S. aureus (MSSA). Seventy-four percent of the cases had community-acquired (CA) SAB, among whom 69{\%} had been hospitalized previously. Skin and soft tissue infections (SSTI) (30{\%}) and respiratory infections (24{\%}) were the common sources of bacteremia. The overall case fatality rate was 27{\%}, and a similar percentage (23{\%}) of patients discontinued therapy due to a poor medical outcome. The PVL gene was detected in 16{\%} of S. aureus isolates, predominantly in CA-. S. aureus (82{\%}). SSTIs and pneumonia were the common sources of bacteremia in 45{\%} of patients infected with a PVL-positive strain. Conclusions: S. aureus is a significant cause of BSI with a case fatality rate comparable to those of other developing nations. The upsurge in MRSA rates is alarming in our setup. Antibiotic stewardship and strict control of antibiotic use must be implemented by health care professionals to curb the increasing trend in MRSA BSIs.",
author = "Eshwara, {Vandana Kalwaje} and Frenil Munim and Chaitanya Tellapragada and Asha Kamath and Muralidhar Varma and Lewis, {Leslie Edward} and Chiranjay Mukhopadhyay",
year = "2013",
month = "11",
doi = "10.1016/j.ijid.2013.06.002",
language = "English",
volume = "17",
pages = "1051--1055",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
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T1 - Staphylococcus aureus bacteremia in an Indian tertiary care hospital

T2 - Observational study on clinical epidemiology, resistance characteristics, and carriage of the Panton-Valentine leukocidin gene

AU - Eshwara, Vandana Kalwaje

AU - Munim, Frenil

AU - Tellapragada, Chaitanya

AU - Kamath, Asha

AU - Varma, Muralidhar

AU - Lewis, Leslie Edward

AU - Mukhopadhyay, Chiranjay

PY - 2013/11

Y1 - 2013/11

N2 - Objectives: To analyze the epidemiology and laboratory characteristics of Staphylococcus aureus bacteremia (SAB) in an Indian tertiary care hospital. Methods: We collected clinical, epidemiological, and laboratory data of all cases of SAB during August 2010 through July 2011. All isolates were tested for the Panton-Valentine leukocidin (PVL) gene. Results: Eighteen percent of all blood stream infections (BSIs) were attributable to S. aureus. Among a total of 70 cases of SAB, 54% were due to methicillin-resistant S. aureus (MRSA) and 46% to methicillin-susceptible S. aureus (MSSA). Seventy-four percent of the cases had community-acquired (CA) SAB, among whom 69% had been hospitalized previously. Skin and soft tissue infections (SSTI) (30%) and respiratory infections (24%) were the common sources of bacteremia. The overall case fatality rate was 27%, and a similar percentage (23%) of patients discontinued therapy due to a poor medical outcome. The PVL gene was detected in 16% of S. aureus isolates, predominantly in CA-. S. aureus (82%). SSTIs and pneumonia were the common sources of bacteremia in 45% of patients infected with a PVL-positive strain. Conclusions: S. aureus is a significant cause of BSI with a case fatality rate comparable to those of other developing nations. The upsurge in MRSA rates is alarming in our setup. Antibiotic stewardship and strict control of antibiotic use must be implemented by health care professionals to curb the increasing trend in MRSA BSIs.

AB - Objectives: To analyze the epidemiology and laboratory characteristics of Staphylococcus aureus bacteremia (SAB) in an Indian tertiary care hospital. Methods: We collected clinical, epidemiological, and laboratory data of all cases of SAB during August 2010 through July 2011. All isolates were tested for the Panton-Valentine leukocidin (PVL) gene. Results: Eighteen percent of all blood stream infections (BSIs) were attributable to S. aureus. Among a total of 70 cases of SAB, 54% were due to methicillin-resistant S. aureus (MRSA) and 46% to methicillin-susceptible S. aureus (MSSA). Seventy-four percent of the cases had community-acquired (CA) SAB, among whom 69% had been hospitalized previously. Skin and soft tissue infections (SSTI) (30%) and respiratory infections (24%) were the common sources of bacteremia. The overall case fatality rate was 27%, and a similar percentage (23%) of patients discontinued therapy due to a poor medical outcome. The PVL gene was detected in 16% of S. aureus isolates, predominantly in CA-. S. aureus (82%). SSTIs and pneumonia were the common sources of bacteremia in 45% of patients infected with a PVL-positive strain. Conclusions: S. aureus is a significant cause of BSI with a case fatality rate comparable to those of other developing nations. The upsurge in MRSA rates is alarming in our setup. Antibiotic stewardship and strict control of antibiotic use must be implemented by health care professionals to curb the increasing trend in MRSA BSIs.

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JF - International Journal of Infectious Diseases

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