Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers

Ananya Madiyal, Vidya Ajila, Subhas G. Babu, Shruthi Hegde, Suchetha Kumari, Medhini Madi, Sonika Achalli, Priyadharshini Alva, Harshini Ullal

Research output: Contribution to journalArticle

Abstract

Background: Use of tobacco is often implicated in the development of oral diseases. Questionable accuracy of the traditional questionnaires to assess cigarette exposure necessitates the use of biomarkers like thiocyanate which provide a definitive quantitative measure. Objective: To assess the rise in the level of thiocyanate for measurement of smoking behaviour in adults. Materials and methods: Serum and salivary thiocyanate levels were estimated in 20 non-smokers, 20 ex-smokers and 40 smokers. Smokers were divided into two groups based on the presence or absence of oral mucosal lesions. Results: The mean serum and salivary thiocyanate levels were increased significantly in smokers when compared to non-smokers and ex-smokers. The levels were not significantly different between ex-smokers and non-smokers and between smokers with tobacco related oral mucosal lesions and those without. Statistically significant correlation was seen between the serum and salivary levels of thiocyanate. Conclusion: This study highlights the high level of thiocyanate in the serum and saliva of smokers when compared to non-smokers and ex-smokers. Significant increase in thiocyanate level was also seen in saliva. Hence it can be stated that saliva can be used as a reliable, non-invasive tool to assess smoking behaviour in the population and its changes over time.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalAfrican Health Sciences
Volume18
Issue number3
DOIs
Publication statusPublished - 01-09-2018
Externally publishedYes

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Saliva
Serum
Mouth Diseases
Smoking
Smokeless Tobacco
Tobacco Use
thiocyanate
Tobacco Products
Biomarkers
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Madiyal, A., Ajila, V., Babu, S. G., Hegde, S., Kumari, S., Madi, M., ... Ullal, H. (2018). Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers. African Health Sciences, 18(3), 727-736. https://doi.org/10.4314/ahs.v18i3.31
Madiyal, Ananya ; Ajila, Vidya ; Babu, Subhas G. ; Hegde, Shruthi ; Kumari, Suchetha ; Madi, Medhini ; Achalli, Sonika ; Alva, Priyadharshini ; Ullal, Harshini. / Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers. In: African Health Sciences. 2018 ; Vol. 18, No. 3. pp. 727-736.
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Madiyal, A, Ajila, V, Babu, SG, Hegde, S, Kumari, S, Madi, M, Achalli, S, Alva, P & Ullal, H 2018, 'Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers', African Health Sciences, vol. 18, no. 3, pp. 727-736. https://doi.org/10.4314/ahs.v18i3.31

Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers. / Madiyal, Ananya; Ajila, Vidya; Babu, Subhas G.; Hegde, Shruthi; Kumari, Suchetha; Madi, Medhini; Achalli, Sonika; Alva, Priyadharshini; Ullal, Harshini.

In: African Health Sciences, Vol. 18, No. 3, 01.09.2018, p. 727-736.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Status of thiocyanate levels in the serum and saliva of non-smokers, ex-smokers and smokers

AU - Madiyal, Ananya

AU - Ajila, Vidya

AU - Babu, Subhas G.

AU - Hegde, Shruthi

AU - Kumari, Suchetha

AU - Madi, Medhini

AU - Achalli, Sonika

AU - Alva, Priyadharshini

AU - Ullal, Harshini

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Use of tobacco is often implicated in the development of oral diseases. Questionable accuracy of the traditional questionnaires to assess cigarette exposure necessitates the use of biomarkers like thiocyanate which provide a definitive quantitative measure. Objective: To assess the rise in the level of thiocyanate for measurement of smoking behaviour in adults. Materials and methods: Serum and salivary thiocyanate levels were estimated in 20 non-smokers, 20 ex-smokers and 40 smokers. Smokers were divided into two groups based on the presence or absence of oral mucosal lesions. Results: The mean serum and salivary thiocyanate levels were increased significantly in smokers when compared to non-smokers and ex-smokers. The levels were not significantly different between ex-smokers and non-smokers and between smokers with tobacco related oral mucosal lesions and those without. Statistically significant correlation was seen between the serum and salivary levels of thiocyanate. Conclusion: This study highlights the high level of thiocyanate in the serum and saliva of smokers when compared to non-smokers and ex-smokers. Significant increase in thiocyanate level was also seen in saliva. Hence it can be stated that saliva can be used as a reliable, non-invasive tool to assess smoking behaviour in the population and its changes over time.

AB - Background: Use of tobacco is often implicated in the development of oral diseases. Questionable accuracy of the traditional questionnaires to assess cigarette exposure necessitates the use of biomarkers like thiocyanate which provide a definitive quantitative measure. Objective: To assess the rise in the level of thiocyanate for measurement of smoking behaviour in adults. Materials and methods: Serum and salivary thiocyanate levels were estimated in 20 non-smokers, 20 ex-smokers and 40 smokers. Smokers were divided into two groups based on the presence or absence of oral mucosal lesions. Results: The mean serum and salivary thiocyanate levels were increased significantly in smokers when compared to non-smokers and ex-smokers. The levels were not significantly different between ex-smokers and non-smokers and between smokers with tobacco related oral mucosal lesions and those without. Statistically significant correlation was seen between the serum and salivary levels of thiocyanate. Conclusion: This study highlights the high level of thiocyanate in the serum and saliva of smokers when compared to non-smokers and ex-smokers. Significant increase in thiocyanate level was also seen in saliva. Hence it can be stated that saliva can be used as a reliable, non-invasive tool to assess smoking behaviour in the population and its changes over time.

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