Strategies for drug delivery to the central nervous system by systemic route

Narayanan Kasinathan, Hitesh V. Jagani, Angel Treasa Alex, Subrahmanyam M. Volety, J. Venkata Rao

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Context: Delivery of a drug into the central nervous system (CNS) is considered difficult. Most of the drugs discovered over the past decade are biological, which are high in molecular weight and polar in nature. The delivery of such drugs across the blood-brain barrier presents problems. Objective: This review discusses some of the options available to reach the CNS by systemic route. The focus is mainly on the recent developments in systemic delivery of a drug to the CNS. Materials and methods: Databases such as Scopus, Google scholar, Science Direct, SciFinder and online journals were referred for preparing this article including 89 references. Results: There are at least nine strategies that could be adopted to achieve the required drug concentration in the CNS. Conclusion: The recent developments in drug delivery are very promising to deliver biologicals into the CNS.

Original languageEnglish
Pages (from-to)243-257
Number of pages15
JournalDrug Delivery
Volume22
Issue number3
DOIs
Publication statusPublished - 01-05-2015

Fingerprint

Central Nervous System
Central Nervous System Agents
Pharmaceutical Preparations
Blood-Brain Barrier
Molecular Weight
Databases

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{7e4ba2660f4e43e49c53d80451b0a475,
title = "Strategies for drug delivery to the central nervous system by systemic route",
abstract = "Context: Delivery of a drug into the central nervous system (CNS) is considered difficult. Most of the drugs discovered over the past decade are biological, which are high in molecular weight and polar in nature. The delivery of such drugs across the blood-brain barrier presents problems. Objective: This review discusses some of the options available to reach the CNS by systemic route. The focus is mainly on the recent developments in systemic delivery of a drug to the CNS. Materials and methods: Databases such as Scopus, Google scholar, Science Direct, SciFinder and online journals were referred for preparing this article including 89 references. Results: There are at least nine strategies that could be adopted to achieve the required drug concentration in the CNS. Conclusion: The recent developments in drug delivery are very promising to deliver biologicals into the CNS.",
author = "Narayanan Kasinathan and Jagani, {Hitesh V.} and Alex, {Angel Treasa} and Volety, {Subrahmanyam M.} and {Venkata Rao}, J.",
year = "2015",
month = "5",
day = "1",
doi = "10.3109/10717544.2013.878858",
language = "English",
volume = "22",
pages = "243--257",
journal = "Drug Delivery",
issn = "1071-7544",
publisher = "Informa Healthcare",
number = "3",

}

Strategies for drug delivery to the central nervous system by systemic route. / Kasinathan, Narayanan; Jagani, Hitesh V.; Alex, Angel Treasa; Volety, Subrahmanyam M.; Venkata Rao, J.

In: Drug Delivery, Vol. 22, No. 3, 01.05.2015, p. 243-257.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Strategies for drug delivery to the central nervous system by systemic route

AU - Kasinathan, Narayanan

AU - Jagani, Hitesh V.

AU - Alex, Angel Treasa

AU - Volety, Subrahmanyam M.

AU - Venkata Rao, J.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Context: Delivery of a drug into the central nervous system (CNS) is considered difficult. Most of the drugs discovered over the past decade are biological, which are high in molecular weight and polar in nature. The delivery of such drugs across the blood-brain barrier presents problems. Objective: This review discusses some of the options available to reach the CNS by systemic route. The focus is mainly on the recent developments in systemic delivery of a drug to the CNS. Materials and methods: Databases such as Scopus, Google scholar, Science Direct, SciFinder and online journals were referred for preparing this article including 89 references. Results: There are at least nine strategies that could be adopted to achieve the required drug concentration in the CNS. Conclusion: The recent developments in drug delivery are very promising to deliver biologicals into the CNS.

AB - Context: Delivery of a drug into the central nervous system (CNS) is considered difficult. Most of the drugs discovered over the past decade are biological, which are high in molecular weight and polar in nature. The delivery of such drugs across the blood-brain barrier presents problems. Objective: This review discusses some of the options available to reach the CNS by systemic route. The focus is mainly on the recent developments in systemic delivery of a drug to the CNS. Materials and methods: Databases such as Scopus, Google scholar, Science Direct, SciFinder and online journals were referred for preparing this article including 89 references. Results: There are at least nine strategies that could be adopted to achieve the required drug concentration in the CNS. Conclusion: The recent developments in drug delivery are very promising to deliver biologicals into the CNS.

UR - http://www.scopus.com/inward/record.url?scp=84930455892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930455892&partnerID=8YFLogxK

U2 - 10.3109/10717544.2013.878858

DO - 10.3109/10717544.2013.878858

M3 - Review article

VL - 22

SP - 243

EP - 257

JO - Drug Delivery

JF - Drug Delivery

SN - 1071-7544

IS - 3

ER -