Streptococcus pneumoniae and Haemophilus species colonization in health care workers: The launch of invasive infections? Infectious Diseases

Supram Hosuru Subramanya, Sangita Thapa, Sanjiv Kumar Dwedi, Shishir Gokhale, Brijesh Sathian, Niranjan Nayak, Indira Bairy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Streptococcus pneumoniae and Haemophilus influenzae are important human pathogens. The risk of airborne and droplet-transmitted respiratory tract infections in healthcare workers (HCW) is substantial. The aim of this study was to determine the extent of oropharyngeal colonization with S. pneumoniae and Haemophilus spp. their antibiogram and risk factors of colonization in HCW at a tertiary care center, Western Nepal. Methods: During 3 month period, 100 oropharyngeal swab specimens were collected from HCW of Manipal Teaching Hospital and 50 from non HCW from community. All the 150 specimens were screened for Haemophilus spp. and S. pneumoniae by standard techniques. Serotyping of H. influenzae type b was done by using specific antiserum. Antibiotic sensitivity patterns of isolates were determined by modified Kirby Bauer disc diffusion method. Association between the groups was analyzed using the Pearson χ2 test and Fisher exact test. A forward step logistic regression model was used to identify significant predictors for colonization. Result: Sixty-five percent of HCW were colonized with S. pneumoniae and/or Haemophilus species compared to 32 % of non-HCW. Health care workers had odd ratio (OR) 3.946 [CI (1.916, 8.128)] times more tendency of colonization compared to non-HCW (P < 0.05). Pneumococcal colonization was observed high among smokers (81.5 %). Amongst HCW, post graduate resident doctors had higher rate of colonization (83.3 %) followed by interns (64.9 %), least being amongst the laboratory workers (58.3 %). Conclusion: The higher rate of colonization amongst HCW raises the possibility of occupational risk as well as horizontal spread of infections.

Original languageEnglish
Article number66
JournalBMC Research Notes
Volume9
Issue number1
DOIs
Publication statusPublished - 04-02-2016

Fingerprint

Haemophilus
Streptococcus pneumoniae
Health care
Communicable Diseases
Occupational risks
Delivery of Health Care
Pathogens
Infection
Logistics
Immune Sera
Teaching
Anti-Bacterial Agents
Disk Diffusion Antimicrobial Tests
Logistic Models
Serotyping
Haemophilus influenzae type b
Nepal
Haemophilus influenzae
Microbial Sensitivity Tests
Tertiary Care Centers

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hosuru Subramanya, Supram ; Thapa, Sangita ; Dwedi, Sanjiv Kumar ; Gokhale, Shishir ; Sathian, Brijesh ; Nayak, Niranjan ; Bairy, Indira. / Streptococcus pneumoniae and Haemophilus species colonization in health care workers : The launch of invasive infections? Infectious Diseases. In: BMC Research Notes. 2016 ; Vol. 9, No. 1.
@article{71af169b93254982ae8087466103e854,
title = "Streptococcus pneumoniae and Haemophilus species colonization in health care workers: The launch of invasive infections? Infectious Diseases",
abstract = "Background: Streptococcus pneumoniae and Haemophilus influenzae are important human pathogens. The risk of airborne and droplet-transmitted respiratory tract infections in healthcare workers (HCW) is substantial. The aim of this study was to determine the extent of oropharyngeal colonization with S. pneumoniae and Haemophilus spp. their antibiogram and risk factors of colonization in HCW at a tertiary care center, Western Nepal. Methods: During 3 month period, 100 oropharyngeal swab specimens were collected from HCW of Manipal Teaching Hospital and 50 from non HCW from community. All the 150 specimens were screened for Haemophilus spp. and S. pneumoniae by standard techniques. Serotyping of H. influenzae type b was done by using specific antiserum. Antibiotic sensitivity patterns of isolates were determined by modified Kirby Bauer disc diffusion method. Association between the groups was analyzed using the Pearson χ2 test and Fisher exact test. A forward step logistic regression model was used to identify significant predictors for colonization. Result: Sixty-five percent of HCW were colonized with S. pneumoniae and/or Haemophilus species compared to 32 {\%} of non-HCW. Health care workers had odd ratio (OR) 3.946 [CI (1.916, 8.128)] times more tendency of colonization compared to non-HCW (P < 0.05). Pneumococcal colonization was observed high among smokers (81.5 {\%}). Amongst HCW, post graduate resident doctors had higher rate of colonization (83.3 {\%}) followed by interns (64.9 {\%}), least being amongst the laboratory workers (58.3 {\%}). Conclusion: The higher rate of colonization amongst HCW raises the possibility of occupational risk as well as horizontal spread of infections.",
author = "{Hosuru Subramanya}, Supram and Sangita Thapa and Dwedi, {Sanjiv Kumar} and Shishir Gokhale and Brijesh Sathian and Niranjan Nayak and Indira Bairy",
year = "2016",
month = "2",
day = "4",
doi = "10.1186/s13104-016-1877-x",
language = "English",
volume = "9",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "BioMed Central",
number = "1",

}

Streptococcus pneumoniae and Haemophilus species colonization in health care workers : The launch of invasive infections? Infectious Diseases. / Hosuru Subramanya, Supram; Thapa, Sangita; Dwedi, Sanjiv Kumar; Gokhale, Shishir; Sathian, Brijesh; Nayak, Niranjan; Bairy, Indira.

In: BMC Research Notes, Vol. 9, No. 1, 66, 04.02.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Streptococcus pneumoniae and Haemophilus species colonization in health care workers

T2 - The launch of invasive infections? Infectious Diseases

AU - Hosuru Subramanya, Supram

AU - Thapa, Sangita

AU - Dwedi, Sanjiv Kumar

AU - Gokhale, Shishir

AU - Sathian, Brijesh

AU - Nayak, Niranjan

AU - Bairy, Indira

PY - 2016/2/4

Y1 - 2016/2/4

N2 - Background: Streptococcus pneumoniae and Haemophilus influenzae are important human pathogens. The risk of airborne and droplet-transmitted respiratory tract infections in healthcare workers (HCW) is substantial. The aim of this study was to determine the extent of oropharyngeal colonization with S. pneumoniae and Haemophilus spp. their antibiogram and risk factors of colonization in HCW at a tertiary care center, Western Nepal. Methods: During 3 month period, 100 oropharyngeal swab specimens were collected from HCW of Manipal Teaching Hospital and 50 from non HCW from community. All the 150 specimens were screened for Haemophilus spp. and S. pneumoniae by standard techniques. Serotyping of H. influenzae type b was done by using specific antiserum. Antibiotic sensitivity patterns of isolates were determined by modified Kirby Bauer disc diffusion method. Association between the groups was analyzed using the Pearson χ2 test and Fisher exact test. A forward step logistic regression model was used to identify significant predictors for colonization. Result: Sixty-five percent of HCW were colonized with S. pneumoniae and/or Haemophilus species compared to 32 % of non-HCW. Health care workers had odd ratio (OR) 3.946 [CI (1.916, 8.128)] times more tendency of colonization compared to non-HCW (P < 0.05). Pneumococcal colonization was observed high among smokers (81.5 %). Amongst HCW, post graduate resident doctors had higher rate of colonization (83.3 %) followed by interns (64.9 %), least being amongst the laboratory workers (58.3 %). Conclusion: The higher rate of colonization amongst HCW raises the possibility of occupational risk as well as horizontal spread of infections.

AB - Background: Streptococcus pneumoniae and Haemophilus influenzae are important human pathogens. The risk of airborne and droplet-transmitted respiratory tract infections in healthcare workers (HCW) is substantial. The aim of this study was to determine the extent of oropharyngeal colonization with S. pneumoniae and Haemophilus spp. their antibiogram and risk factors of colonization in HCW at a tertiary care center, Western Nepal. Methods: During 3 month period, 100 oropharyngeal swab specimens were collected from HCW of Manipal Teaching Hospital and 50 from non HCW from community. All the 150 specimens were screened for Haemophilus spp. and S. pneumoniae by standard techniques. Serotyping of H. influenzae type b was done by using specific antiserum. Antibiotic sensitivity patterns of isolates were determined by modified Kirby Bauer disc diffusion method. Association between the groups was analyzed using the Pearson χ2 test and Fisher exact test. A forward step logistic regression model was used to identify significant predictors for colonization. Result: Sixty-five percent of HCW were colonized with S. pneumoniae and/or Haemophilus species compared to 32 % of non-HCW. Health care workers had odd ratio (OR) 3.946 [CI (1.916, 8.128)] times more tendency of colonization compared to non-HCW (P < 0.05). Pneumococcal colonization was observed high among smokers (81.5 %). Amongst HCW, post graduate resident doctors had higher rate of colonization (83.3 %) followed by interns (64.9 %), least being amongst the laboratory workers (58.3 %). Conclusion: The higher rate of colonization amongst HCW raises the possibility of occupational risk as well as horizontal spread of infections.

UR - http://www.scopus.com/inward/record.url?scp=84959495060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959495060&partnerID=8YFLogxK

U2 - 10.1186/s13104-016-1877-x

DO - 10.1186/s13104-016-1877-x

M3 - Article

C2 - 26847639

AN - SCOPUS:84959495060

VL - 9

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

IS - 1

M1 - 66

ER -