TY - JOUR
T1 - Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer's Agents
T2 - A Comprehensive Review
AU - Das, Subham
AU - Akbar, Saleem
AU - Ahmed, Bahar
AU - Dewangan, Rikeshwar Prasad
AU - Iqubal, Ashif
AU - Pottoo, Faheem Hyder
AU - Joseph, Alex
N1 - Funding Information:
Subham Das is thankful to the Manipal Academy of Higher Education (MAHE) for providing Dr.T.M.A. Pai Doctoral Fellowship. Saleem Akbar is thankful to the Indian Council of Medical Research (ICMR) for the Senior Re- search Fellowship (SRF). The authors also acknowledge with thanks to Manipal College of Pharmaceutical Sciences and Jamia Hamdard for providing facilities for this work. The authors are also thankful to BioRender.com.
Publisher Copyright:
© 2022 Bentham Science Publishers.
PY - 2022
Y1 - 2022
N2 - Pyrimidine is an aromatic and heterocyclic organic compound containing a 6-membered ring consisting of four carbon and two nitrogen atoms on alternative positions. Pyrimidine scaffolds described their existence in the medicinal chemist's cause for their synthesizing practicability and nonpoisonous nature. However, the reason behind neurological disorders is still an open challenge for scientific research and development organizations. Efficacy voids are widespread before researchers, despite high throughput research in the field of anti-Alzheimer's drugs.Researchers have constantly investigated all the probabilities for restraining the unwanted adverse effects of the anti-Alzheimer's agents and are focusing more extensively to rehabilitate neurological disorders. The scientific literature on drug development has been an aspiration to medicinal chemists and other researchers to facilitate further research. Therefore, this review emphasizes the structure-activity relationship (SAR) based approach and the pharmacological advancements of pyrimidine moiety in the new era of therapeutics as anti-Alzheimer's agents.
AB - Pyrimidine is an aromatic and heterocyclic organic compound containing a 6-membered ring consisting of four carbon and two nitrogen atoms on alternative positions. Pyrimidine scaffolds described their existence in the medicinal chemist's cause for their synthesizing practicability and nonpoisonous nature. However, the reason behind neurological disorders is still an open challenge for scientific research and development organizations. Efficacy voids are widespread before researchers, despite high throughput research in the field of anti-Alzheimer's drugs.Researchers have constantly investigated all the probabilities for restraining the unwanted adverse effects of the anti-Alzheimer's agents and are focusing more extensively to rehabilitate neurological disorders. The scientific literature on drug development has been an aspiration to medicinal chemists and other researchers to facilitate further research. Therefore, this review emphasizes the structure-activity relationship (SAR) based approach and the pharmacological advancements of pyrimidine moiety in the new era of therapeutics as anti-Alzheimer's agents.
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U2 - 10.2174/1871527320666210804161400
DO - 10.2174/1871527320666210804161400
M3 - Review article
C2 - 34348636
AN - SCOPUS:85134589602
SN - 1871-5273
VL - 21
SP - 926
EP - 939
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 10
ER -