Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity

S. S. Godipurge, J. S. Biradar, N. J. Biradar, H. P. Shivarudrappa, S. Yallappa, B. S. Hungund, K. Sreedhara Ranganath Pai

Research output: Contribution to journalArticle

Abstract

Two new alkaloids, designated as hypocretine 1 and 2, have been extracted from the aerial parts of Rivea hypocrateriformis, and their structures were established as 1-(4-(((1R,5S,6R)-(4-acetyl-2,6-dibutylphenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2,6-dibutylphenyl)ethan-1-one and 1-(4-((3-(4-acetyl-2-butyl-6-(4-hydroxybutyl)phenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2-butyl-6-(4-hydroxybutyl)phenyl)ethan-1-one. These alkaloids were further characterized by mass and NMR spectral data analysis. Further studies were conducted to evaluate their antihemolytic and cytotoxic activity. The extracted compounds exhibited potent antihemolytic activity against cow erythrocytes. The results of the MTT assay for cytotoxicity revealed the antiproliferative activity of compounds 1and 2 against MCF-7 breast cancer cell line.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalChemistry of Natural Compounds
Volume54
Issue number1
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

aerial parts
alkaloids
breast neoplasms
spectral analysis
cytotoxicity
data analysis
erythrocytes
cell lines
cows
assays
neoplasm cells

All Science Journal Classification (ASJC) codes

  • Plant Science

Cite this

Godipurge, S. S. ; Biradar, J. S. ; Biradar, N. J. ; Shivarudrappa, H. P. ; Yallappa, S. ; Hungund, B. S. ; Sreedhara Ranganath Pai, K. / Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity. In: Chemistry of Natural Compounds. 2018 ; Vol. 54, No. 1. pp. 142-146.
@article{9824bbef44df4a4b81e5e251dc83822c,
title = "Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity",
abstract = "Two new alkaloids, designated as hypocretine 1 and 2, have been extracted from the aerial parts of Rivea hypocrateriformis, and their structures were established as 1-(4-(((1R,5S,6R)-(4-acetyl-2,6-dibutylphenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2,6-dibutylphenyl)ethan-1-one and 1-(4-((3-(4-acetyl-2-butyl-6-(4-hydroxybutyl)phenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2-butyl-6-(4-hydroxybutyl)phenyl)ethan-1-one. These alkaloids were further characterized by mass and NMR spectral data analysis. Further studies were conducted to evaluate their antihemolytic and cytotoxic activity. The extracted compounds exhibited potent antihemolytic activity against cow erythrocytes. The results of the MTT assay for cytotoxicity revealed the antiproliferative activity of compounds 1and 2 against MCF-7 breast cancer cell line.",
author = "Godipurge, {S. S.} and Biradar, {J. S.} and Biradar, {N. J.} and Shivarudrappa, {H. P.} and S. Yallappa and Hungund, {B. S.} and {Sreedhara Ranganath Pai}, K.",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s10600-018-2277-3",
language = "English",
volume = "54",
pages = "142--146",
journal = "Chemistry of Natural Compounds",
issn = "0009-3130",
publisher = "Springer New York",
number = "1",

}

Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity. / Godipurge, S. S.; Biradar, J. S.; Biradar, N. J.; Shivarudrappa, H. P.; Yallappa, S.; Hungund, B. S.; Sreedhara Ranganath Pai, K.

In: Chemistry of Natural Compounds, Vol. 54, No. 1, 01.01.2018, p. 142-146.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Structural Elucidation of Alkaloids from Aerial Parts of Rivea hypocrateriformis and Their Antihemolytic and Cytotoxic Activity

AU - Godipurge, S. S.

AU - Biradar, J. S.

AU - Biradar, N. J.

AU - Shivarudrappa, H. P.

AU - Yallappa, S.

AU - Hungund, B. S.

AU - Sreedhara Ranganath Pai, K.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Two new alkaloids, designated as hypocretine 1 and 2, have been extracted from the aerial parts of Rivea hypocrateriformis, and their structures were established as 1-(4-(((1R,5S,6R)-(4-acetyl-2,6-dibutylphenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2,6-dibutylphenyl)ethan-1-one and 1-(4-((3-(4-acetyl-2-butyl-6-(4-hydroxybutyl)phenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2-butyl-6-(4-hydroxybutyl)phenyl)ethan-1-one. These alkaloids were further characterized by mass and NMR spectral data analysis. Further studies were conducted to evaluate their antihemolytic and cytotoxic activity. The extracted compounds exhibited potent antihemolytic activity against cow erythrocytes. The results of the MTT assay for cytotoxicity revealed the antiproliferative activity of compounds 1and 2 against MCF-7 breast cancer cell line.

AB - Two new alkaloids, designated as hypocretine 1 and 2, have been extracted from the aerial parts of Rivea hypocrateriformis, and their structures were established as 1-(4-(((1R,5S,6R)-(4-acetyl-2,6-dibutylphenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2,6-dibutylphenyl)ethan-1-one and 1-(4-((3-(4-acetyl-2-butyl-6-(4-hydroxybutyl)phenoxy)-8-methyl-8-azabicyclo[3.2.1]octan-6-yl)oxy)-2-butyl-6-(4-hydroxybutyl)phenyl)ethan-1-one. These alkaloids were further characterized by mass and NMR spectral data analysis. Further studies were conducted to evaluate their antihemolytic and cytotoxic activity. The extracted compounds exhibited potent antihemolytic activity against cow erythrocytes. The results of the MTT assay for cytotoxicity revealed the antiproliferative activity of compounds 1and 2 against MCF-7 breast cancer cell line.

UR - http://www.scopus.com/inward/record.url?scp=85041918280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041918280&partnerID=8YFLogxK

U2 - 10.1007/s10600-018-2277-3

DO - 10.1007/s10600-018-2277-3

M3 - Article

VL - 54

SP - 142

EP - 146

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 1

ER -