Structurally nanoengineered antimicrobial peptide polymers: design, synthesis and biomedical applications

Ronisha Ramamurthy, Chetan H. Mehta, Usha Y. Nayak

Research output: Contribution to journalReview articlepeer-review

Abstract

Abstract: Antimicrobial resistance not only increases the contagiousness of infectious diseases but also a threat for the future as it is one of the health care concern around the globe. Conventional antibiotics are unsuccessful in combating chronic infections caused by multidrug-resistant (MDR) bacteria, therefore it is important to design and develop novel strategies to tackle this problems. Among various novel strategies, Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs) have been introduced in recent years to overcome this global health care issue and they are found to be more efficient in their performance. Many facile methods are adapted to synthesize complex SNAPPs with required dimensions and unique functionalities. Their unique characteristics and remarkable properties have been exploited for their immense applications in various fields including biomedicine, targeting therapies, gene delivery, bioimaging, and many more. This review article deals with its background, design, synthesis, mechanism of action, and wider applications in various fields of SNAPPs. Graphic abstract: [Figure not available: see fulltext.].

Original languageEnglish
Article number139
JournalWorld Journal of Microbiology and Biotechnology
Volume37
Issue number8
DOIs
Publication statusPublished - 08-2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Physiology
  • Applied Microbiology and Biotechnology

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