Studies of disintegrant properties of seed mucilage of Ocimum gratissimum

Ravikumar [Unknown], A. Shirwaikar, S. Prabu, R. Mahalaxmi, K. Rajendran, C. Kumar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Dispersible tablets of Metformin Hydrochloride were prepared using Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder as disintegrants. Specifications for herbal raw materials and finished products were set according to the Committee for Proprietary Medicinal Products. Several formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. The formulations were prepared with different proportions of Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder. The formulated tablets had good appearance and better drug release properties as compared to the marketed conventional tablets. The study revealed that Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder were effective as disintegrants in low concentrations (5%). The study further revealed a poor relation between the swelling index and disintegrating efficiency. Mucilage extracted from Ocimum gratissimum seeds was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The mucilage extracted is devoid of toxicity. Studies indicated that the extracted mucilage is a good pharmaceutical adjuvant, specifically a disintegrating agent.
Original languageEnglish
Pages (from-to)753-758
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume69
Issue number6
Publication statusPublished - 2007

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Ocimum
Seeds
Powders
Tablets
Pharmaceutic Adjuvants
Metformin
Hardness
Safety
Weights and Measures

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[Unknown], R., Shirwaikar, A., Prabu, S., Mahalaxmi, R., Rajendran, K., & Kumar, C. (2007). Studies of disintegrant properties of seed mucilage of Ocimum gratissimum. Indian Journal of Pharmaceutical Sciences, 69(6), 753-758.
[Unknown], Ravikumar ; Shirwaikar, A. ; Prabu, S. ; Mahalaxmi, R. ; Rajendran, K. ; Kumar, C. / Studies of disintegrant properties of seed mucilage of Ocimum gratissimum. In: Indian Journal of Pharmaceutical Sciences. 2007 ; Vol. 69, No. 6. pp. 753-758.
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title = "Studies of disintegrant properties of seed mucilage of Ocimum gratissimum",
abstract = "Dispersible tablets of Metformin Hydrochloride were prepared using Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder as disintegrants. Specifications for herbal raw materials and finished products were set according to the Committee for Proprietary Medicinal Products. Several formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. The formulations were prepared with different proportions of Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder. The formulated tablets had good appearance and better drug release properties as compared to the marketed conventional tablets. The study revealed that Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder were effective as disintegrants in low concentrations (5{\%}). The study further revealed a poor relation between the swelling index and disintegrating efficiency. Mucilage extracted from Ocimum gratissimum seeds was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The mucilage extracted is devoid of toxicity. Studies indicated that the extracted mucilage is a good pharmaceutical adjuvant, specifically a disintegrating agent.",
author = "Ravikumar [Unknown] and A. Shirwaikar and S. Prabu and R. Mahalaxmi and K. Rajendran and C. Kumar",
note = "Cited By :10 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Gulf Pharmacy College, Gulf Medical University, Ajman, United Arab Emirates; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: metformin, 1115-70-4, 657-24-9 Tradenames: glyciphage Manufacturers: zydus research, India References: Seager, H., Drug-delivery products and the Zydis fast-dissolving dosage form (1998) J Pharm Pharmacol, 50, pp. 375-382; Chang, R.K., Guo, X., Burnside, B.A., Couch, R.A., Fast-dissolving tablets (2000) Pharm Tech, 24, pp. 52-58; Dobetti, L., Fast-melting tablets: Developments and technologies (2001) Pharm Tech, (SUPPL.), p. 44; Kuchekar, B.S., Bhise, S.B., Arumugam, V., Design of fast dissolving tablets (2001) Indian J Pharm Edu, 35, p. 150; (1999) Martindale: The complete drug reference, p. 758. , Parfitt K. editor, 32nd ed. UK: Pharmaceutical Press;; Dollery, C., (1992) AHFS drug information, p. 663. , American Society of Health-System Pharamacists: Bethesda, MD, USA;; Pharmeuropa, Electronic Issue 19.3 (1998) Strasbourg, (France): The European Pharmacopoeia Forum, p. 547. , European directorate for the quality of medicines and healthcare; Sastry, S.V., Nyshadham, J.R., Fix, J.A., Recent technological advances in oral drug delivery: A review (2000) Pharm Sci Tech, 3, pp. 138-145; Indurwade, N.H., Rajyaguru, T.H., Nakhat, P.D., Novel approach: Fast dissolving tablets (2002) Indian Drugs, 39, pp. 405-409; Stepensky D, Friedman M, Srour W, Hoffmann A. Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation. J Control Release 2001;71:107-15; Vidon, N., Chaussade, S., Noel, M., Franchisseur, C., Huchet, B., Berneir, J.J., Metformin in the digestive tract (1988) Diabetes Res Clin Pract, 4, pp. 223-229; Monif, T., Mahlhotra, A.K., Kapoor, V.P., Cassia fustula seed galactomannan: Potential binding agent for pharmaceutical formulation (1992) Indian J Pharm Sci, 54, pp. 234-240; Kapoor, V.P., Banerji, R., Prakash, D., Leguminous seeds: Potential industrial sources for gum, fat and protein (1992) J Sci Ind Res, 51, pp. 1-22; Kakrani HK, Jain NK. A study on binding properties of guggul gum. Indian J Hosp Pharm 1981;100-2; Bhunvara, N.S., Khorana, M.L., Studies on suspending property of mucilages of hyprophila spinosa (1985) Indian Drugs, 22, pp. 500-502; Whistler, R.L., (1973) Industrial gums, , 2nd ed. New York: Academic Press;; The Wealth of India, VIII, New Delhi: CSIR Publication; 2001. p. 80; Khanna, M., Nandhi, R.C., Singh, S., Jain, G.K., Sarin, J.P., Standardization of pure isapgol mucilage for pharmaceutical use (1988) Indian J Pharm Sci, 50, pp. 238-240; Baveja, S.K., Ranga Rao, K.V., Arora, J., Examination of natural gums and mucilages as sustaining materials in tablet dosage forms-Part II (1989) Indian J Pharm Sci, 51, pp. 115-118; British Pharmacopoeia II, London: Her Majesty's Stationery Office; 1988. p. 140; Knudsen, L.F., Curtiss, J.M., The use of the angular formulation in biological assays (1947) J Am Stat Soc, 42, pp. 282-296; Marshall, K., (1987) The Theory and practice of Industrial Pharmacy, p. 67. , Lachman, Leon, Liberman, Kanig HA, editors, 3rd ed. Mumbai: Varghese Publishing House;; Fiese, E.F., Hagen, T.A., (1987) The Theory and practice of Industrial Pharmacy, p. 183. , Lachman, Leon, Liberman HA, Kanig JL, editors, 3rd ed. Mumbai: Varghese Publishing House;; Banker, G.S., Anderson, G.R., (1987) The Theory and practice of Industrial Pharmacy, p. 293. , Lachman L, Liberman HA, Kanig JL, editors, 3rd ed. Mumbai: Varghese Publishing House;; Indian Pharmacopoeia, 4th ed. II, New Delhi: Controller of Publications, Govt. of India; 1996. p.735; Klancke, J., Dissolution testing of orally disintegrating tablets (2003) Diss Tech, pp. 6-8. , May; Siewert M, Dressman J, Brown CK, Shah VP. FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms. AAPS Pharm Sci Tech 2003;4:article 7UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-40749140811&partnerID=40&md5=a894d475d38295258979f82f498141a6",
year = "2007",
language = "English",
volume = "69",
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journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
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}

[Unknown], R, Shirwaikar, A, Prabu, S, Mahalaxmi, R, Rajendran, K & Kumar, C 2007, 'Studies of disintegrant properties of seed mucilage of Ocimum gratissimum', Indian Journal of Pharmaceutical Sciences, vol. 69, no. 6, pp. 753-758.

Studies of disintegrant properties of seed mucilage of Ocimum gratissimum. / [Unknown], Ravikumar; Shirwaikar, A.; Prabu, S.; Mahalaxmi, R.; Rajendran, K.; Kumar, C.

In: Indian Journal of Pharmaceutical Sciences, Vol. 69, No. 6, 2007, p. 753-758.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Studies of disintegrant properties of seed mucilage of Ocimum gratissimum

AU - [Unknown], Ravikumar

AU - Shirwaikar, A.

AU - Prabu, S.

AU - Mahalaxmi, R.

AU - Rajendran, K.

AU - Kumar, C.

N1 - Cited By :10 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Gulf Pharmacy College, Gulf Medical University, Ajman, United Arab Emirates; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: metformin, 1115-70-4, 657-24-9 Tradenames: glyciphage Manufacturers: zydus research, India References: Seager, H., Drug-delivery products and the Zydis fast-dissolving dosage form (1998) J Pharm Pharmacol, 50, pp. 375-382; Chang, R.K., Guo, X., Burnside, B.A., Couch, R.A., Fast-dissolving tablets (2000) Pharm Tech, 24, pp. 52-58; Dobetti, L., Fast-melting tablets: Developments and technologies (2001) Pharm Tech, (SUPPL.), p. 44; Kuchekar, B.S., Bhise, S.B., Arumugam, V., Design of fast dissolving tablets (2001) Indian J Pharm Edu, 35, p. 150; (1999) Martindale: The complete drug reference, p. 758. , Parfitt K. editor, 32nd ed. UK: Pharmaceutical Press;; Dollery, C., (1992) AHFS drug information, p. 663. , American Society of Health-System Pharamacists: Bethesda, MD, USA;; Pharmeuropa, Electronic Issue 19.3 (1998) Strasbourg, (France): The European Pharmacopoeia Forum, p. 547. , European directorate for the quality of medicines and healthcare; Sastry, S.V., Nyshadham, J.R., Fix, J.A., Recent technological advances in oral drug delivery: A review (2000) Pharm Sci Tech, 3, pp. 138-145; Indurwade, N.H., Rajyaguru, T.H., Nakhat, P.D., Novel approach: Fast dissolving tablets (2002) Indian Drugs, 39, pp. 405-409; Stepensky D, Friedman M, Srour W, Hoffmann A. Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation. J Control Release 2001;71:107-15; Vidon, N., Chaussade, S., Noel, M., Franchisseur, C., Huchet, B., Berneir, J.J., Metformin in the digestive tract (1988) Diabetes Res Clin Pract, 4, pp. 223-229; Monif, T., Mahlhotra, A.K., Kapoor, V.P., Cassia fustula seed galactomannan: Potential binding agent for pharmaceutical formulation (1992) Indian J Pharm Sci, 54, pp. 234-240; Kapoor, V.P., Banerji, R., Prakash, D., Leguminous seeds: Potential industrial sources for gum, fat and protein (1992) J Sci Ind Res, 51, pp. 1-22; Kakrani HK, Jain NK. A study on binding properties of guggul gum. Indian J Hosp Pharm 1981;100-2; Bhunvara, N.S., Khorana, M.L., Studies on suspending property of mucilages of hyprophila spinosa (1985) Indian Drugs, 22, pp. 500-502; Whistler, R.L., (1973) Industrial gums, , 2nd ed. New York: Academic Press;; The Wealth of India, VIII, New Delhi: CSIR Publication; 2001. p. 80; Khanna, M., Nandhi, R.C., Singh, S., Jain, G.K., Sarin, J.P., Standardization of pure isapgol mucilage for pharmaceutical use (1988) Indian J Pharm Sci, 50, pp. 238-240; Baveja, S.K., Ranga Rao, K.V., Arora, J., Examination of natural gums and mucilages as sustaining materials in tablet dosage forms-Part II (1989) Indian J Pharm Sci, 51, pp. 115-118; British Pharmacopoeia II, London: Her Majesty's Stationery Office; 1988. p. 140; Knudsen, L.F., Curtiss, J.M., The use of the angular formulation in biological assays (1947) J Am Stat Soc, 42, pp. 282-296; Marshall, K., (1987) The Theory and practice of Industrial Pharmacy, p. 67. , Lachman, Leon, Liberman, Kanig HA, editors, 3rd ed. Mumbai: Varghese Publishing House;; Fiese, E.F., Hagen, T.A., (1987) The Theory and practice of Industrial Pharmacy, p. 183. , Lachman, Leon, Liberman HA, Kanig JL, editors, 3rd ed. Mumbai: Varghese Publishing House;; Banker, G.S., Anderson, G.R., (1987) The Theory and practice of Industrial Pharmacy, p. 293. , Lachman L, Liberman HA, Kanig JL, editors, 3rd ed. Mumbai: Varghese Publishing House;; Indian Pharmacopoeia, 4th ed. II, New Delhi: Controller of Publications, Govt. of India; 1996. p.735; Klancke, J., Dissolution testing of orally disintegrating tablets (2003) Diss Tech, pp. 6-8. , May; Siewert M, Dressman J, Brown CK, Shah VP. FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms. AAPS Pharm Sci Tech 2003;4:article 7UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-40749140811&partnerID=40&md5=a894d475d38295258979f82f498141a6

PY - 2007

Y1 - 2007

N2 - Dispersible tablets of Metformin Hydrochloride were prepared using Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder as disintegrants. Specifications for herbal raw materials and finished products were set according to the Committee for Proprietary Medicinal Products. Several formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. The formulations were prepared with different proportions of Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder. The formulated tablets had good appearance and better drug release properties as compared to the marketed conventional tablets. The study revealed that Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder were effective as disintegrants in low concentrations (5%). The study further revealed a poor relation between the swelling index and disintegrating efficiency. Mucilage extracted from Ocimum gratissimum seeds was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The mucilage extracted is devoid of toxicity. Studies indicated that the extracted mucilage is a good pharmaceutical adjuvant, specifically a disintegrating agent.

AB - Dispersible tablets of Metformin Hydrochloride were prepared using Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder as disintegrants. Specifications for herbal raw materials and finished products were set according to the Committee for Proprietary Medicinal Products. Several formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. The formulations were prepared with different proportions of Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder. The formulated tablets had good appearance and better drug release properties as compared to the marketed conventional tablets. The study revealed that Ocimum gratissimum mucilage powder and Ocimum gratissimum seed powder were effective as disintegrants in low concentrations (5%). The study further revealed a poor relation between the swelling index and disintegrating efficiency. Mucilage extracted from Ocimum gratissimum seeds was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The mucilage extracted is devoid of toxicity. Studies indicated that the extracted mucilage is a good pharmaceutical adjuvant, specifically a disintegrating agent.

M3 - Article

VL - 69

SP - 753

EP - 758

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 6

ER -