Studies on arylfuran derivatives. Part VII. Synthesis and characterization of some Mannich bases carrying halophenylfuryl moieties as promising antibacterial agents

B. Shivarama Holla, M. K. Shivananda, M. Shalini Shenoy, Georgy Antony

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Abstract

A series of 4-[5-(halophenyl)-2-furfurylidene)]amino-3-mercapto-5-substituted-1,2,4 -triazoles (3) were synthesized. Aminomethylation of 3 with formaldehyde and a secondary amine furnished Mannich bases, 4. Both Schiff bases and Mannich bases were characterized on the basis of IR, NMR, mass spectral data and elemental analysis. All the newly synthesized compounds were tested for their antibacterial activities. Some of them carrying morpholino and N-methylpiperazino residues were found to be promising antibacterial agents.

Original languageEnglish
Pages (from-to)531-535
Number of pages5
JournalFarmaco
Volume53
Issue number8-9
DOIs
Publication statusPublished - 30-08-1998

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

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