Studies on solubility parameter of amoxycillin trihydrate: Influence on in vitro release and antibacterial activity

H. Karanth, V.R. Josyula

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Amoxycillin trihydrate, a broad spectrum antibiotic, is a poorly water-soluble drug and has low bioavailability on oral administration. Solubility parameter of the drug (δ2) was evaluated in blends of ethyl acetate-propylene glycol and water-propylene glycol in the ratios 100:0, 75:25, 50:50, 25:75 and 0:100. The results obtained were compared with the δ2 values obtained using Molar Volume method and Fedor's group substitution method. Ethyl acetate-propylene glycol (75:25) was found to give maximum solubility with an experimental value of 13.32 H in comparison to the theoretical values of 13.25 H by molar volume method and 15.46 H from Fedor's group substitution method. In vitro drug release studies and antibacterial effect were evaluated with an intention to study the effect of the solvent blends on the drug release and its activity. In the in vitro studies, the water-propylene glycol (100:0) and the ethyl acetate-propylene glycol (50:50) ratios gave maximum release of the drug in their respective blends. The results of the in vitro studies correlated with the antibiotic Study conducted on both binary blends.
Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume67
Issue number3
Publication statusPublished - 2005

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Propylene Glycol
Amoxicillin
Solubility
Water
Anti-Bacterial Agents
Pharmaceutical Preparations
Biological Availability
Oral Administration
In Vitro Techniques
Drug Liberation
ethyl acetate

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title = "Studies on solubility parameter of amoxycillin trihydrate: Influence on in vitro release and antibacterial activity",
abstract = "Amoxycillin trihydrate, a broad spectrum antibiotic, is a poorly water-soluble drug and has low bioavailability on oral administration. Solubility parameter of the drug (δ2) was evaluated in blends of ethyl acetate-propylene glycol and water-propylene glycol in the ratios 100:0, 75:25, 50:50, 25:75 and 0:100. The results obtained were compared with the δ2 values obtained using Molar Volume method and Fedor's group substitution method. Ethyl acetate-propylene glycol (75:25) was found to give maximum solubility with an experimental value of 13.32 H in comparison to the theoretical values of 13.25 H by molar volume method and 15.46 H from Fedor's group substitution method. In vitro drug release studies and antibacterial effect were evaluated with an intention to study the effect of the solvent blends on the drug release and its activity. In the in vitro studies, the water-propylene glycol (100:0) and the ethyl acetate-propylene glycol (50:50) ratios gave maximum release of the drug in their respective blends. The results of the in vitro studies correlated with the antibiotic Study conducted on both binary blends.",
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note = "Cited By :5 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Josyula, V. R.; Department of Pharmacy Management, College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: jvrao56@hotmail.com References: Petri Jr., W.A., (2001) Goodman and Gilman's The Pharmacological Basis of Therapeutics, p. 1189. , Hardman, J.G, Limbird, L.E, Molinoff, P.B, Ruddon, W.R. and Gilman, A.G, Eds, 10th Edn, McGraw-Hill Companies, Inc, New York; Yalkowsky S.H., In; Eds. Techniques of Solubilization of Drugs, 12th Edn., Marcel Dekker Inc., New York, 1981, 92; Krause, G.M., Cross, J.M., (1951) J. Amer. Pharm. Assoc. Sci. Ed, 40, p. 137; Martin, A., Bustamante, P., Chun, A.H.C., (1994) Physical Pharmacy, , Eds, 4th Edn, Waverly International, Maryland, 212; Mullins, L., (1954) Chem. Rev, 54, p. 289; Khalil, S.A., Martin, A.N., (1967) J. Pharm. Sei, 56, p. 1223; Adjei, A., Newberger, J., Stavchansky, S., Martin, A., (1984) J. Pharm. Sci, 73, p. 742; Hildebrand, J.H., Prausnitz, J.M. and Scott, R., In; Eds. Regular and Related Solutions, Van Nostrand Reinhold, New York, 1970, 22; Hansen, C and Beerbower, A., In; Eds., Encyclopedia of Chemical Technology, Suppli. 1, 2nd Edn., Wiley, New York, 1971; Subrahmanyam, C.V.S., Sarasija, S., (1999) Eur. J. Pharm. Biopharm, 47, p. 289; Fedors, R.F., (1974) Polym. Eng. Sci, 14, p. 147; Indian Pharmacopoeia, Ministry of Health and Family Welfare, Govt. of India, Delhi, 1996, 50UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-34249817941&partnerID=40&md5=877bab4eb782d962c76d2a21b17f3e5f",
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Studies on solubility parameter of amoxycillin trihydrate: Influence on in vitro release and antibacterial activity. / Karanth, H.; Josyula, V.R.

In: Indian Journal of Pharmaceutical Sciences, Vol. 67, No. 3, 2005, p. 342-345.

Research output: Contribution to journalArticle

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N2 - Amoxycillin trihydrate, a broad spectrum antibiotic, is a poorly water-soluble drug and has low bioavailability on oral administration. Solubility parameter of the drug (δ2) was evaluated in blends of ethyl acetate-propylene glycol and water-propylene glycol in the ratios 100:0, 75:25, 50:50, 25:75 and 0:100. The results obtained were compared with the δ2 values obtained using Molar Volume method and Fedor's group substitution method. Ethyl acetate-propylene glycol (75:25) was found to give maximum solubility with an experimental value of 13.32 H in comparison to the theoretical values of 13.25 H by molar volume method and 15.46 H from Fedor's group substitution method. In vitro drug release studies and antibacterial effect were evaluated with an intention to study the effect of the solvent blends on the drug release and its activity. In the in vitro studies, the water-propylene glycol (100:0) and the ethyl acetate-propylene glycol (50:50) ratios gave maximum release of the drug in their respective blends. The results of the in vitro studies correlated with the antibiotic Study conducted on both binary blends.

AB - Amoxycillin trihydrate, a broad spectrum antibiotic, is a poorly water-soluble drug and has low bioavailability on oral administration. Solubility parameter of the drug (δ2) was evaluated in blends of ethyl acetate-propylene glycol and water-propylene glycol in the ratios 100:0, 75:25, 50:50, 25:75 and 0:100. The results obtained were compared with the δ2 values obtained using Molar Volume method and Fedor's group substitution method. Ethyl acetate-propylene glycol (75:25) was found to give maximum solubility with an experimental value of 13.32 H in comparison to the theoretical values of 13.25 H by molar volume method and 15.46 H from Fedor's group substitution method. In vitro drug release studies and antibacterial effect were evaluated with an intention to study the effect of the solvent blends on the drug release and its activity. In the in vitro studies, the water-propylene glycol (100:0) and the ethyl acetate-propylene glycol (50:50) ratios gave maximum release of the drug in their respective blends. The results of the in vitro studies correlated with the antibiotic Study conducted on both binary blends.

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JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

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