Study and evaluation of the various cutaneous adverse drug reactions in Kasturba Hospital, Manipal

S. Ghosh, L. Acharya, P. Rao

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the adverse drug reactions were also studied. Adverse drug reactions were also assessed for causality, using Naranjo's scale, severity, and preventability, using Hartwig et al. scale. Adverse drug reaction attributes to 77% of the hospital visit. Incidence of reported cutaneous adverse drug reactions, were 2.85%. Majority of the adverse drug reactions (96%) were of type B. Antibiotics (30%), were the common class of drugs, causing a cutaneous adverse drug reactions. Maximum number of adverse drug reactions were due to Acetaminophen, Amoxicillin, antitubercular drugs, and Phenytoin. Most of the adverse drug reactions were managed by withdrawal of drug (81%), and 58% patients were recovered from the reaction. Naranjos scale classifies, 29 as probable, 21 as possible, and 3 as definite adverse drug reactions. Most of the adverse drug reactions were of moderate severity, however 13 adverse drug reactions were severe. All the adverse drug reactions were probably preventable on extreme caution.
Original languageEnglish
Pages (from-to)212-215
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume68
Issue number2
Publication statusPublished - 2006

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Drug-Related Side Effects and Adverse Reactions
Skin
Causality
Pharmaceutical Preparations
Adverse Drug Reaction Reporting Systems
Antitubercular Agents
Hospital Departments
Incidence
Amoxicillin
Phenytoin
Acetaminophen
Dermatology
Pharmacists

Cite this

@article{bad8ccc20c2e4f94b667c75bab298601,
title = "Study and evaluation of the various cutaneous adverse drug reactions in Kasturba Hospital, Manipal",
abstract = "The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the adverse drug reactions were also studied. Adverse drug reactions were also assessed for causality, using Naranjo's scale, severity, and preventability, using Hartwig et al. scale. Adverse drug reaction attributes to 77{\%} of the hospital visit. Incidence of reported cutaneous adverse drug reactions, were 2.85{\%}. Majority of the adverse drug reactions (96{\%}) were of type B. Antibiotics (30{\%}), were the common class of drugs, causing a cutaneous adverse drug reactions. Maximum number of adverse drug reactions were due to Acetaminophen, Amoxicillin, antitubercular drugs, and Phenytoin. Most of the adverse drug reactions were managed by withdrawal of drug (81{\%}), and 58{\%} patients were recovered from the reaction. Naranjos scale classifies, 29 as probable, 21 as possible, and 3 as definite adverse drug reactions. Most of the adverse drug reactions were of moderate severity, however 13 adverse drug reactions were severe. All the adverse drug reactions were probably preventable on extreme caution.",
author = "S. Ghosh and L. Acharya and P. Rao",
note = "Cited By :12 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Acharya, L.; Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: leela.da@manipal.edu Chemicals/CAS: amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; carbamazepine, 298-46-4, 8047-84-5; ethambutol, 10054-05-4, 1070-11-7, 3577-94-4, 74-55-5; isoniazid, 54-85-3, 62229-51-0, 65979-32-0; paracetamol, 103-90-2; phenytoin, 57-41-0, 630-93-3; pyrazinamide, 98-96-4; rifampicin, 13292-46-1; roxithromycin, 80214-83-1 References: Beard, K., (2001) Adverse Drug Reactions, 1st Edn., p. 1. , Lee, A., Eds., Pharmaceutical Press, London; Bigby, M., Jick, S., Jick, H., Arndt, K.A., (1986) J. Amer. Med. Assoc., 256, p. 3358; Lee, A., Thomson, J., (2001) Adverse Drug Reactions, 1st Edn., p. 19. , Lee, A., Eds., Pharmaceutical Press, London; Barbara, S.M., (2001) Comprehensive Pharmacy Review, 4th Edn., p. 416. , Shargel, L., Eds., Lippincott Williams & Wilkins, London; Edwards, I.R., (1997) Avery's Drug Treatment, 4th Edn., p. 261. , Speight, T.M. and Nicholas, H.G., Eds., Adis International; (1973) Int. J. Epidemiol., 2, p. 167; Roujeau, J.C., Kelly, J.P., Naldi, L., (1995) N. Engl. J. Med., 333, p. 1600; Bigby, M., (2001) Arch. Dermatol., 137, p. 765; Bern, J.I., Mann, R.D., Rawlins, M.D., (1998) Brit. Med. J., 296, p. 1319; Faich, G.A., Knapp, D., Dreis, M., Turner, W., (1987) J. Amer. Med. Assoc., 257, p. 2068; Naldi, L., Conforti, A., Venegoni, M., (1999) Brit. J. Clin. Pharmacol., 48, p. 839; Kushwaha, K.P., Verma, R.B., Singh, Y.D., Rathi, A.K., (1994) Indian J. Pediatr., 61, p. 357; Naina, H.H., Philip, A.N., Dennis, P.W., (1999) Pharmacotherapy; A Pathophysiologic Approach, 4th Edn., p. 1505. , Dipiro, T.J., Eds., Appleton and Lange, Stamford, Cannecticut; Hartwig, S.C., Siege, I.J., Schneider, P.J., (1992) Amer. J. Hosp. Pharm., 49, p. 2229; Naranjo, C.A., Busto, U., Sellers, E.M., (1981) Clin. Pharmacol. Ther., 30, p. 239",
year = "2006",
language = "English",
volume = "68",
pages = "212--215",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
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}

Study and evaluation of the various cutaneous adverse drug reactions in Kasturba Hospital, Manipal. / Ghosh, S.; Acharya, L.; Rao, P.

In: Indian Journal of Pharmaceutical Sciences, Vol. 68, No. 2, 2006, p. 212-215.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Ghosh, S.

AU - Acharya, L.

AU - Rao, P.

N1 - Cited By :12 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Acharya, L.; Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: leela.da@manipal.edu Chemicals/CAS: amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; carbamazepine, 298-46-4, 8047-84-5; ethambutol, 10054-05-4, 1070-11-7, 3577-94-4, 74-55-5; isoniazid, 54-85-3, 62229-51-0, 65979-32-0; paracetamol, 103-90-2; phenytoin, 57-41-0, 630-93-3; pyrazinamide, 98-96-4; rifampicin, 13292-46-1; roxithromycin, 80214-83-1 References: Beard, K., (2001) Adverse Drug Reactions, 1st Edn., p. 1. , Lee, A., Eds., Pharmaceutical Press, London; Bigby, M., Jick, S., Jick, H., Arndt, K.A., (1986) J. Amer. Med. Assoc., 256, p. 3358; Lee, A., Thomson, J., (2001) Adverse Drug Reactions, 1st Edn., p. 19. , Lee, A., Eds., Pharmaceutical Press, London; Barbara, S.M., (2001) Comprehensive Pharmacy Review, 4th Edn., p. 416. , Shargel, L., Eds., Lippincott Williams & Wilkins, London; Edwards, I.R., (1997) Avery's Drug Treatment, 4th Edn., p. 261. , Speight, T.M. and Nicholas, H.G., Eds., Adis International; (1973) Int. J. Epidemiol., 2, p. 167; Roujeau, J.C., Kelly, J.P., Naldi, L., (1995) N. Engl. J. Med., 333, p. 1600; Bigby, M., (2001) Arch. Dermatol., 137, p. 765; Bern, J.I., Mann, R.D., Rawlins, M.D., (1998) Brit. Med. J., 296, p. 1319; Faich, G.A., Knapp, D., Dreis, M., Turner, W., (1987) J. Amer. Med. Assoc., 257, p. 2068; Naldi, L., Conforti, A., Venegoni, M., (1999) Brit. J. Clin. Pharmacol., 48, p. 839; Kushwaha, K.P., Verma, R.B., Singh, Y.D., Rathi, A.K., (1994) Indian J. Pediatr., 61, p. 357; Naina, H.H., Philip, A.N., Dennis, P.W., (1999) Pharmacotherapy; A Pathophysiologic Approach, 4th Edn., p. 1505. , Dipiro, T.J., Eds., Appleton and Lange, Stamford, Cannecticut; Hartwig, S.C., Siege, I.J., Schneider, P.J., (1992) Amer. J. Hosp. Pharm., 49, p. 2229; Naranjo, C.A., Busto, U., Sellers, E.M., (1981) Clin. Pharmacol. Ther., 30, p. 239

PY - 2006

Y1 - 2006

N2 - The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the adverse drug reactions were also studied. Adverse drug reactions were also assessed for causality, using Naranjo's scale, severity, and preventability, using Hartwig et al. scale. Adverse drug reaction attributes to 77% of the hospital visit. Incidence of reported cutaneous adverse drug reactions, were 2.85%. Majority of the adverse drug reactions (96%) were of type B. Antibiotics (30%), were the common class of drugs, causing a cutaneous adverse drug reactions. Maximum number of adverse drug reactions were due to Acetaminophen, Amoxicillin, antitubercular drugs, and Phenytoin. Most of the adverse drug reactions were managed by withdrawal of drug (81%), and 58% patients were recovered from the reaction. Naranjos scale classifies, 29 as probable, 21 as possible, and 3 as definite adverse drug reactions. Most of the adverse drug reactions were of moderate severity, however 13 adverse drug reactions were severe. All the adverse drug reactions were probably preventable on extreme caution.

AB - The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the adverse drug reactions were also studied. Adverse drug reactions were also assessed for causality, using Naranjo's scale, severity, and preventability, using Hartwig et al. scale. Adverse drug reaction attributes to 77% of the hospital visit. Incidence of reported cutaneous adverse drug reactions, were 2.85%. Majority of the adverse drug reactions (96%) were of type B. Antibiotics (30%), were the common class of drugs, causing a cutaneous adverse drug reactions. Maximum number of adverse drug reactions were due to Acetaminophen, Amoxicillin, antitubercular drugs, and Phenytoin. Most of the adverse drug reactions were managed by withdrawal of drug (81%), and 58% patients were recovered from the reaction. Naranjos scale classifies, 29 as probable, 21 as possible, and 3 as definite adverse drug reactions. Most of the adverse drug reactions were of moderate severity, however 13 adverse drug reactions were severe. All the adverse drug reactions were probably preventable on extreme caution.

M3 - Article

VL - 68

SP - 212

EP - 215

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 2

ER -