Study of clinical profile and antibiotic sensitivity pattern in culture-positive typhoid fever cases

Ashwini Kumar, Vinay Pandit, Seema Shetty, Chythra R. Rao, Sanjay Pattanshetty, Charmaine M. Samarasinghe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Salmonella enteric serotype Typhi has created a significant therapeutic problem as these strains have developed resistance to the commonly used antimicrobials for the treatment of typhoid fever. Objectives: To assess the clinical profile and sensitivity patterns to anti-typhoid drugs. Materials and Methods: A retrospective analysis of 106 culture-positive typhoid cases admitted in a tertiary care hospital during the years 2005-2008. Results: Records of 106 patients were evaluated, 83 (78.3%) males and 23 (21.7%) females. Fever was present in all patients. Headache in 63 (59.4%) patients and generalized body ache in 53 (32.5%) patients were the most common symptoms, while spleenomegaly in 47 (44.3%) patients and hepatomegaly in 42 (39.6%) patients were the common presenting signs. A maximum sensitivity of 96.6% was observed with cephalosporins, whereas a resistance of 29.2% was seen with fluoroquinolones. Conclusion: A high degree of sensitivity was noted to chloramphenicol, ampicillin and sulphonamides, showing a trend of roll-back of sensitivity to conventional antibiotics.

Original languageEnglish
Pages (from-to)256-258
Number of pages3
JournalIndian Journal of Community Medicine
Volume37
Issue number4
DOIs
Publication statusPublished - 01-10-2012

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Typhoid Fever
Anti-Bacterial Agents
Hepatomegaly
Fluoroquinolones
Sulfonamides
Chloramphenicol
Tertiary Healthcare
Cephalosporins
Ampicillin
Tertiary Care Centers
Salmonella
Headache
Clinical Studies
Fever
Pain
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

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abstract = "Background: Salmonella enteric serotype Typhi has created a significant therapeutic problem as these strains have developed resistance to the commonly used antimicrobials for the treatment of typhoid fever. Objectives: To assess the clinical profile and sensitivity patterns to anti-typhoid drugs. Materials and Methods: A retrospective analysis of 106 culture-positive typhoid cases admitted in a tertiary care hospital during the years 2005-2008. Results: Records of 106 patients were evaluated, 83 (78.3{\%}) males and 23 (21.7{\%}) females. Fever was present in all patients. Headache in 63 (59.4{\%}) patients and generalized body ache in 53 (32.5{\%}) patients were the most common symptoms, while spleenomegaly in 47 (44.3{\%}) patients and hepatomegaly in 42 (39.6{\%}) patients were the common presenting signs. A maximum sensitivity of 96.6{\%} was observed with cephalosporins, whereas a resistance of 29.2{\%} was seen with fluoroquinolones. Conclusion: A high degree of sensitivity was noted to chloramphenicol, ampicillin and sulphonamides, showing a trend of roll-back of sensitivity to conventional antibiotics.",
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Study of clinical profile and antibiotic sensitivity pattern in culture-positive typhoid fever cases. / Kumar, Ashwini; Pandit, Vinay; Shetty, Seema; Rao, Chythra R.; Pattanshetty, Sanjay; Samarasinghe, Charmaine M.

In: Indian Journal of Community Medicine, Vol. 37, No. 4, 01.10.2012, p. 256-258.

Research output: Contribution to journalArticle

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