Study on evaluation of monosodium glutamate induced oxidative damge on renal tissue on adult Wistar rats

N. A. Vinodini, A. K. Nayanatara, C. Ramaswamy, Anu V. Ranade, Rekha D. Kini, K. M. Damadara Gowda, B. Ahamed, Shabarinath, Ramesh Bhat

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Abstract

Objective: To study the effect of monosodium glutamate (MSG) on biochemical parameters of renal tissue and certain blood parameters in adult albino rats. Methods: Wistar rats of either sex (average weight of 200 g) were divided into control group and experimental group. The experimental group of rats received MSG intraperitoneally (4 g/kg/bw) for a duration of 30 days whereas the control group received distilled water intraperitoneally of the same volume. At the end of the experiment period, 2 ml of blood was collected through cardiac puncture for the estimation of the blood parameters. The kidneys were carefully dissected out and sliced into small pieces and centrifuged. The supernatant obtained was used for the estimation of lipid peroxidation, malondialdehyde(MDA), glutathione (GSH) and superoxide dismutase (SOD). Results: There was an increase in the level of tissue lipid peroxidation (16.402 ± 2.290, P < 0.0001), blood urea (29.468 ± 0.944, P < 0.0001) and blood creatnine (0.963 ±0.015,P <0.5) in the experimental group than when compared to the controls(5.881 ± 0.875, 13.551 ± 0.946 and 0.376 ± 0.052 respectively) and the tissue GSH (2.82 ± 0. 856, P < 0.0001) and SOD (5.150 ± 1.098, P<0.0001) level was decreased in the experimental group than the control(7.268 ± 0.489 and 13.086 ±0.611). Conclusion: The results of our study suggest that exposure to MSG may cause an adverse effect on the renal function which might be due to oxidative stress induced by MSG on the renal tissue.

Original languageEnglish
Pages (from-to)144-147
Number of pages4
JournalJournal of Chinese Clinical Medicine
Volume5
Issue number3
Publication statusPublished - 01-03-2010

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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