Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications

S. Shanmugasundar, N. Kannan, E. Sundaravadivel, Sarang Zsolt, K. S. Mukunthan, J. Manokaran, J. Narendranath, V. P. Kamalakannan, P. Kavitha, V. Prabhu, N. Balasubramanian

Research output: Contribution to journalArticle

Abstract

Background The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acry-late/polystyrene/silica composite membrane. Methods The characteristic of the composite was investigated through modern state art of instrumentation. Results The functional groups attached to the polymer was absorbed by FTIR. The FTIR spectrum confirm that the blend was mixed thoroughly and the formation of unite intimately between the polymers. The membranes were observed by SEM for its surface homogeneity which depends upon the composition of the two blending polymers. The captured SEM images showed the formation of microcracks on the surface, which was evidently controlled by varying the constituent polymer ratios. The prepared blend membranes with 2:1 ratio of PMMA/ PS/Si displayed higher water uptake compared to other blended membranes. The composite membranes had good hydroxyl apatite growth in SBF solution. Furthermore, the in vitro cytotoxicity studies carried out by MTT method, using RAW macrophage cells showed that all the samples exhibited excellent cell viability. Conclusion The inflammatory response of composite with equal concentration of PMMA-PS were performed and observed no inflammation in comparison with control and other tested concentrations.

Original languageEnglish
Article numbere0209948
JournalPLoS One
Volume14
Issue number3
DOIs
Publication statusPublished - 01-03-2019

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Dental Pharmaceutical Preparations
nanocomposites
Nanocomposites
Polystyrenes
polystyrenes
Polymethyl Methacrylate
Drug delivery
Silicon Dioxide
silica
polymers
Polymers
teeth
inflammation
Membranes
drugs
Composite membranes
composite materials
Fourier Transform Infrared Spectroscopy
Apatites
apatite

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Shanmugasundar, S., Kannan, N., Sundaravadivel, E., Zsolt, S., Mukunthan, K. S., Manokaran, J., ... Balasubramanian, N. (2019). Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications. PLoS One, 14(3), [e0209948]. https://doi.org/10.1371/journal.pone.0209948
Shanmugasundar, S. ; Kannan, N. ; Sundaravadivel, E. ; Zsolt, Sarang ; Mukunthan, K. S. ; Manokaran, J. ; Narendranath, J. ; Kamalakannan, V. P. ; Kavitha, P. ; Prabhu, V. ; Balasubramanian, N. / Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications. In: PLoS One. 2019 ; Vol. 14, No. 3.
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Shanmugasundar, S, Kannan, N, Sundaravadivel, E, Zsolt, S, Mukunthan, KS, Manokaran, J, Narendranath, J, Kamalakannan, VP, Kavitha, P, Prabhu, V & Balasubramanian, N 2019, 'Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications', PLoS One, vol. 14, no. 3, e0209948. https://doi.org/10.1371/journal.pone.0209948

Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications. / Shanmugasundar, S.; Kannan, N.; Sundaravadivel, E.; Zsolt, Sarang; Mukunthan, K. S.; Manokaran, J.; Narendranath, J.; Kamalakannan, V. P.; Kavitha, P.; Prabhu, V.; Balasubramanian, N.

In: PLoS One, Vol. 14, No. 3, e0209948, 01.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications

AU - Shanmugasundar, S.

AU - Kannan, N.

AU - Sundaravadivel, E.

AU - Zsolt, Sarang

AU - Mukunthan, K. S.

AU - Manokaran, J.

AU - Narendranath, J.

AU - Kamalakannan, V. P.

AU - Kavitha, P.

AU - Prabhu, V.

AU - Balasubramanian, N.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acry-late/polystyrene/silica composite membrane. Methods The characteristic of the composite was investigated through modern state art of instrumentation. Results The functional groups attached to the polymer was absorbed by FTIR. The FTIR spectrum confirm that the blend was mixed thoroughly and the formation of unite intimately between the polymers. The membranes were observed by SEM for its surface homogeneity which depends upon the composition of the two blending polymers. The captured SEM images showed the formation of microcracks on the surface, which was evidently controlled by varying the constituent polymer ratios. The prepared blend membranes with 2:1 ratio of PMMA/ PS/Si displayed higher water uptake compared to other blended membranes. The composite membranes had good hydroxyl apatite growth in SBF solution. Furthermore, the in vitro cytotoxicity studies carried out by MTT method, using RAW macrophage cells showed that all the samples exhibited excellent cell viability. Conclusion The inflammatory response of composite with equal concentration of PMMA-PS were performed and observed no inflammation in comparison with control and other tested concentrations.

AB - Background The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acry-late/polystyrene/silica composite membrane. Methods The characteristic of the composite was investigated through modern state art of instrumentation. Results The functional groups attached to the polymer was absorbed by FTIR. The FTIR spectrum confirm that the blend was mixed thoroughly and the formation of unite intimately between the polymers. The membranes were observed by SEM for its surface homogeneity which depends upon the composition of the two blending polymers. The captured SEM images showed the formation of microcracks on the surface, which was evidently controlled by varying the constituent polymer ratios. The prepared blend membranes with 2:1 ratio of PMMA/ PS/Si displayed higher water uptake compared to other blended membranes. The composite membranes had good hydroxyl apatite growth in SBF solution. Furthermore, the in vitro cytotoxicity studies carried out by MTT method, using RAW macrophage cells showed that all the samples exhibited excellent cell viability. Conclusion The inflammatory response of composite with equal concentration of PMMA-PS were performed and observed no inflammation in comparison with control and other tested concentrations.

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U2 - 10.1371/journal.pone.0209948

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