Successful treatment of right-sided native valve methicillin-resistant Staphylococcus aureus endocarditis and septicaemia with teicoplanin and rifampicin: A case report

Kavitha Saravu, Chiranjay Mukhopadhyay, Vishwanath Satyanarayanan, Ananth Pai, Ashok Sebastian Komaranchath, Frenil Munim, Barkur Ananthakrishna Shastry, Devasia Tom

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Vancomycin is the drug of choice in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. However, the presence of certain clinical complications like renal failure alters vancomycin pharmacokinetics, leading to drug accumulation and toxicity. This highlights the need to identify an effective substitute for treating MRSA infections when vancomycin cannot be used. We report the case of a 57-y-old Indian male diagnosed with tricuspid valve endocarditis with septicaemia and a right upper lobe cavity caused by MRSA. The patient also presented with renal failure, which precluded the use of vancomycin for treatment. A 6-week regimen of teicoplanin and rifampicin was used instead, and the infection was successfully treated. This case report provides evidence of the effectiveness of teicoplanin and rifampicin in the treatment of MRSA bacteraemia in situations where the use of vancomycin is contraindicated.

Original languageEnglish
Pages (from-to)544-547
Number of pages4
JournalScandinavian Journal of Infectious Diseases
Volume44
Issue number7
DOIs
Publication statusPublished - 01-07-2012

Fingerprint

Teicoplanin
Vancomycin
Rifampin
Methicillin-Resistant Staphylococcus aureus
Endocarditis
Sepsis
Renal Insufficiency
Infection
Therapeutics
Tricuspid Valve
Bacteremia
Drug-Related Side Effects and Adverse Reactions
Pharmacokinetics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Saravu, Kavitha ; Mukhopadhyay, Chiranjay ; Satyanarayanan, Vishwanath ; Pai, Ananth ; Komaranchath, Ashok Sebastian ; Munim, Frenil ; Shastry, Barkur Ananthakrishna ; Tom, Devasia. / Successful treatment of right-sided native valve methicillin-resistant Staphylococcus aureus endocarditis and septicaemia with teicoplanin and rifampicin : A case report. In: Scandinavian Journal of Infectious Diseases. 2012 ; Vol. 44, No. 7. pp. 544-547.
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Successful treatment of right-sided native valve methicillin-resistant Staphylococcus aureus endocarditis and septicaemia with teicoplanin and rifampicin : A case report. / Saravu, Kavitha; Mukhopadhyay, Chiranjay; Satyanarayanan, Vishwanath; Pai, Ananth; Komaranchath, Ashok Sebastian; Munim, Frenil; Shastry, Barkur Ananthakrishna; Tom, Devasia.

In: Scandinavian Journal of Infectious Diseases, Vol. 44, No. 7, 01.07.2012, p. 544-547.

Research output: Contribution to journalArticle

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