Suppurative Cervical Lymphadenitis in Infancy

Microbiology and Sociology

Mitchell L. Worley, Joseph M. Seif, Amy S. Whigham, James W. Mims, Avinash K. Shetty, Adele K. Evans

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective. To investigate the associations between patient age, sociological factors, and the microbiology of pediatric neck infections. Methods. Retrospective chart review of children up to 5 years old who underwent surgical management of suppurative cervical lymphadenitis. Results. A total of 76 individuals met inclusion criteria; 93% of culture-positive infections were caused by Staphylococcus aureus in infants, compared with 59% in children between 13 months and 5 years of age (P =.002). Of the S aureus isolates, 51% were methicillin-resistant S aureus (MRSA) and 49% were methicillin-sensitive S aureus. Methicillin resistance was associated with African American race (P =.004); 67% of participants received empirical antibiotics prior to admission. Of these, 73% received antibiotics in the β-lactam class, and 25% received treatment with clindamycin. Conclusions. Incidence of MRSA is high in infants with cervical lymphadenitis who fail empirical antibiotic therapy and require surgical management. Empirical coverage for cervical lymphadenitis with β-lactam antibiotics may provide inadequate coverage for early infection in this population.

Original languageEnglish
Pages (from-to)629-634
Number of pages6
JournalClinical Pediatrics
Volume54
Issue number7
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

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Lymphadenitis
Sociology
Microbiology
Methicillin Resistance
Anti-Bacterial Agents
Lactams
Infection
Methicillin
Clindamycin
Age Factors
African Americans
Staphylococcus aureus
Neck
Pediatrics
Incidence
Therapeutics
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Worley, M. L., Seif, J. M., Whigham, A. S., Mims, J. W., Shetty, A. K., & Evans, A. K. (2015). Suppurative Cervical Lymphadenitis in Infancy: Microbiology and Sociology. Clinical Pediatrics, 54(7), 629-634. https://doi.org/10.1177/0009922815584548
Worley, Mitchell L. ; Seif, Joseph M. ; Whigham, Amy S. ; Mims, James W. ; Shetty, Avinash K. ; Evans, Adele K. / Suppurative Cervical Lymphadenitis in Infancy : Microbiology and Sociology. In: Clinical Pediatrics. 2015 ; Vol. 54, No. 7. pp. 629-634.
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abstract = "Objective. To investigate the associations between patient age, sociological factors, and the microbiology of pediatric neck infections. Methods. Retrospective chart review of children up to 5 years old who underwent surgical management of suppurative cervical lymphadenitis. Results. A total of 76 individuals met inclusion criteria; 93{\%} of culture-positive infections were caused by Staphylococcus aureus in infants, compared with 59{\%} in children between 13 months and 5 years of age (P =.002). Of the S aureus isolates, 51{\%} were methicillin-resistant S aureus (MRSA) and 49{\%} were methicillin-sensitive S aureus. Methicillin resistance was associated with African American race (P =.004); 67{\%} of participants received empirical antibiotics prior to admission. Of these, 73{\%} received antibiotics in the β-lactam class, and 25{\%} received treatment with clindamycin. Conclusions. Incidence of MRSA is high in infants with cervical lymphadenitis who fail empirical antibiotic therapy and require surgical management. Empirical coverage for cervical lymphadenitis with β-lactam antibiotics may provide inadequate coverage for early infection in this population.",
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Worley, ML, Seif, JM, Whigham, AS, Mims, JW, Shetty, AK & Evans, AK 2015, 'Suppurative Cervical Lymphadenitis in Infancy: Microbiology and Sociology', Clinical Pediatrics, vol. 54, no. 7, pp. 629-634. https://doi.org/10.1177/0009922815584548

Suppurative Cervical Lymphadenitis in Infancy : Microbiology and Sociology. / Worley, Mitchell L.; Seif, Joseph M.; Whigham, Amy S.; Mims, James W.; Shetty, Avinash K.; Evans, Adele K.

In: Clinical Pediatrics, Vol. 54, No. 7, 01.01.2015, p. 629-634.

Research output: Contribution to journalArticle

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N2 - Objective. To investigate the associations between patient age, sociological factors, and the microbiology of pediatric neck infections. Methods. Retrospective chart review of children up to 5 years old who underwent surgical management of suppurative cervical lymphadenitis. Results. A total of 76 individuals met inclusion criteria; 93% of culture-positive infections were caused by Staphylococcus aureus in infants, compared with 59% in children between 13 months and 5 years of age (P =.002). Of the S aureus isolates, 51% were methicillin-resistant S aureus (MRSA) and 49% were methicillin-sensitive S aureus. Methicillin resistance was associated with African American race (P =.004); 67% of participants received empirical antibiotics prior to admission. Of these, 73% received antibiotics in the β-lactam class, and 25% received treatment with clindamycin. Conclusions. Incidence of MRSA is high in infants with cervical lymphadenitis who fail empirical antibiotic therapy and require surgical management. Empirical coverage for cervical lymphadenitis with β-lactam antibiotics may provide inadequate coverage for early infection in this population.

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Worley ML, Seif JM, Whigham AS, Mims JW, Shetty AK, Evans AK. Suppurative Cervical Lymphadenitis in Infancy: Microbiology and Sociology. Clinical Pediatrics. 2015 Jan 1;54(7):629-634. https://doi.org/10.1177/0009922815584548