Sustained-release matrix tablets of terbutaline sulphate

Formulation and in vitro evaluation

N. M. Harish, A. B. Kiran, M. Rathnanand, A. Shirwaikar, K. R P Shenoy

Research output: Contribution to journalArticle

Abstract

The objective of the present study was to develop sustained release matrix tablets of Terbutaline Sulphate used in asthma. The tablets were prepared by wet granulation method using isopropyl alcohol with stearyl alcohol as granulating agent. Hydrophilic matrix materials like Hydroxypropyl methylcellulose (HPMC), hydrophobic polymer such as Eudragit RLPO where used in the study. The granules were evaluated for angle of repose, bulk density, compressibility index, Swelling index, and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility and drug content. The results of dissolution studies indicated that optimized formulation F-5 (drug with HPMC 4KM), E-5 (Drug with HPMC 10 KM), S-5 (Drug with Eudragit RLPO) could extend the drug release up to 12 h. These optimized formulation showed similar release profile as that of the marketed product. All the formulations exhibited Higuchi-dominated drug release. The mechanism of drug release was found to be diffusion controlled.

Original languageEnglish
Pages (from-to)233-235
Number of pages3
JournalIndian Drugs
Volume44
Issue number3
Publication statusPublished - 01-03-2007

Fingerprint

Terbutaline
Tablets
Pharmaceutical Preparations
2-Propanol
Hardness
In Vitro Techniques
Polymers
Asthma
Weights and Measures
Drug Liberation
Hypromellose Derivatives

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Harish, N. M., Kiran, A. B., Rathnanand, M., Shirwaikar, A., & Shenoy, K. R. P. (2007). Sustained-release matrix tablets of terbutaline sulphate: Formulation and in vitro evaluation. Indian Drugs, 44(3), 233-235.
Harish, N. M. ; Kiran, A. B. ; Rathnanand, M. ; Shirwaikar, A. ; Shenoy, K. R P. / Sustained-release matrix tablets of terbutaline sulphate : Formulation and in vitro evaluation. In: Indian Drugs. 2007 ; Vol. 44, No. 3. pp. 233-235.
@article{070e9d8e404542b3af159800889816a8,
title = "Sustained-release matrix tablets of terbutaline sulphate: Formulation and in vitro evaluation",
abstract = "The objective of the present study was to develop sustained release matrix tablets of Terbutaline Sulphate used in asthma. The tablets were prepared by wet granulation method using isopropyl alcohol with stearyl alcohol as granulating agent. Hydrophilic matrix materials like Hydroxypropyl methylcellulose (HPMC), hydrophobic polymer such as Eudragit RLPO where used in the study. The granules were evaluated for angle of repose, bulk density, compressibility index, Swelling index, and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility and drug content. The results of dissolution studies indicated that optimized formulation F-5 (drug with HPMC 4KM), E-5 (Drug with HPMC 10 KM), S-5 (Drug with Eudragit RLPO) could extend the drug release up to 12 h. These optimized formulation showed similar release profile as that of the marketed product. All the formulations exhibited Higuchi-dominated drug release. The mechanism of drug release was found to be diffusion controlled.",
author = "Harish, {N. M.} and Kiran, {A. B.} and M. Rathnanand and A. Shirwaikar and Shenoy, {K. R P}",
year = "2007",
month = "3",
day = "1",
language = "English",
volume = "44",
pages = "233--235",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "3",

}

Harish, NM, Kiran, AB, Rathnanand, M, Shirwaikar, A & Shenoy, KRP 2007, 'Sustained-release matrix tablets of terbutaline sulphate: Formulation and in vitro evaluation', Indian Drugs, vol. 44, no. 3, pp. 233-235.

Sustained-release matrix tablets of terbutaline sulphate : Formulation and in vitro evaluation. / Harish, N. M.; Kiran, A. B.; Rathnanand, M.; Shirwaikar, A.; Shenoy, K. R P.

In: Indian Drugs, Vol. 44, No. 3, 01.03.2007, p. 233-235.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sustained-release matrix tablets of terbutaline sulphate

T2 - Formulation and in vitro evaluation

AU - Harish, N. M.

AU - Kiran, A. B.

AU - Rathnanand, M.

AU - Shirwaikar, A.

AU - Shenoy, K. R P

PY - 2007/3/1

Y1 - 2007/3/1

N2 - The objective of the present study was to develop sustained release matrix tablets of Terbutaline Sulphate used in asthma. The tablets were prepared by wet granulation method using isopropyl alcohol with stearyl alcohol as granulating agent. Hydrophilic matrix materials like Hydroxypropyl methylcellulose (HPMC), hydrophobic polymer such as Eudragit RLPO where used in the study. The granules were evaluated for angle of repose, bulk density, compressibility index, Swelling index, and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility and drug content. The results of dissolution studies indicated that optimized formulation F-5 (drug with HPMC 4KM), E-5 (Drug with HPMC 10 KM), S-5 (Drug with Eudragit RLPO) could extend the drug release up to 12 h. These optimized formulation showed similar release profile as that of the marketed product. All the formulations exhibited Higuchi-dominated drug release. The mechanism of drug release was found to be diffusion controlled.

AB - The objective of the present study was to develop sustained release matrix tablets of Terbutaline Sulphate used in asthma. The tablets were prepared by wet granulation method using isopropyl alcohol with stearyl alcohol as granulating agent. Hydrophilic matrix materials like Hydroxypropyl methylcellulose (HPMC), hydrophobic polymer such as Eudragit RLPO where used in the study. The granules were evaluated for angle of repose, bulk density, compressibility index, Swelling index, and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility and drug content. The results of dissolution studies indicated that optimized formulation F-5 (drug with HPMC 4KM), E-5 (Drug with HPMC 10 KM), S-5 (Drug with Eudragit RLPO) could extend the drug release up to 12 h. These optimized formulation showed similar release profile as that of the marketed product. All the formulations exhibited Higuchi-dominated drug release. The mechanism of drug release was found to be diffusion controlled.

UR - http://www.scopus.com/inward/record.url?scp=79251554999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251554999&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 233

EP - 235

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 3

ER -