Chequerboard and time-kill methods were used to compare the in vitro efficacies of the combinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone-sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. The combinations GAT+CFP and GAT+CFP-SUL were shown to be synergistic for 36.2 and 58.6% of isolates tested, respectively, using the chequerboard method. Time-kill studies with 11 strains showed synergy in 54.5% for the GAT+CFP combination and 72.7% for the GAT+CFP-SUL combination. The agreement between these two methods was found to be 72-81 %. There was a significant difference in synergy between the two combinations tested (P=0.011). © 2008 SGM.
Sivagurunathan, N., Krishnan, S., Venkat Rao, J., Nagappa, A. N., Subrahmanyam, V. M., & Meenashi Vanathi, B. (2008). Synergy of gatifloxacin with cefoperazone and cefoperazone-sulbactam against resistant strains of Pseudomonas aeruginosa. Journal of Medical Microbiology, 57(12), 1514-1517. https://doi.org/10.1099/jmm.0.2008/001636-0