Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives

M. Shivaprasad Shetty, H. S. Anil Kumar, N. V. Anil Kumar

Research output: Contribution to journalArticle

Abstract

A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC50 = 49.70 μg/mL), 3g (IC50 = 79.20 μg/mL), and 3i (IC50 = 48.80 μg/mL) as well as reference drug (IC50 = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.

Original languageEnglish
Pages (from-to)526-530
Number of pages5
JournalPharmaceutical Chemistry Journal
Volume52
Issue number6
DOIs
Publication statusPublished - 01-09-2018

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Coumarins
Amylases
Inhibitory Concentration 50
Acarbose
Hydrazones
Aspergillus niger
Enzymes
Human Body
Glucose
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Shivaprasad Shetty, M. ; Anil Kumar, H. S. ; Anil Kumar, N. V. / Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives. In: Pharmaceutical Chemistry Journal. 2018 ; Vol. 52, No. 6. pp. 526-530.
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Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives. / Shivaprasad Shetty, M.; Anil Kumar, H. S.; Anil Kumar, N. V.

In: Pharmaceutical Chemistry Journal, Vol. 52, No. 6, 01.09.2018, p. 526-530.

Research output: Contribution to journalArticle

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