Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

G. Elias, M.N.A. Rao

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.
Original languageUndefined/Unknown
Pages (from-to)379-380
Number of pages2
JournalEuropean Journal of Medicinal Chemistry
Volume23
Issue number4
DOIs
Publication statusPublished - 1988
Externally publishedYes

Cite this

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title = "Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones",
abstract = "A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. {\circledC} 1988.",
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Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones. / Elias, G.; Rao, M.N.A.

In: European Journal of Medicinal Chemistry, Vol. 23, No. 4, 1988, p. 379-380.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

AU - Elias, G.

AU - Rao, M.N.A.

N1 - cited By 42

PY - 1988

Y1 - 1988

N2 - A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.

AB - A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.

U2 - 10.1016/0223-5234(88)90212-7

DO - 10.1016/0223-5234(88)90212-7

M3 - Article

VL - 23

SP - 379

EP - 380

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

IS - 4

ER -