A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.
Elias, G., & Rao, M. N. A. (1988). Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones. European Journal of Medicinal Chemistry, 23(4), 379-380. https://doi.org/10.1016/0223-5234(88)90212-7