Some new 2,3-disubstituted quinazolin-4-(3H)-ones have been synthesized by the condensation of respective 2-substituted 1,3-benzoxazin-4-ones (4a-b) with different primary amines in equimolar conc. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data. These compounds were tested for invitro antibacterial activity against Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Micrococcus luteus (ATCC 8341), Klebsiella pneumoniae (ATCC 29665) and Escherichia coli (ATCC 25922).
|Number of pages||4|
|Journal||Indian Journal of Heterocyclic Chemistry|
|Publication status||Published - 2008|