Synthesis and antibacterial screening of few new 5-membered heterocyclic sugar hydrazones

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Abstract

Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterial activities. Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newly synthesized compounds were deduced based on spectral data and elemental analyses. Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin. Compound 6a exhibited most potent antibacterial activity against all the tested strains. Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials.

Original languageEnglish
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume9
Issue number3
Publication statusPublished - 01-05-2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

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