Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4- oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes

B. Shivararna Holla, Richard Gonsalves, Shalini Shenoy

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2- bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 μg/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume35
Issue number2
DOIs
Publication statusPublished - 01-01-2000

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Ethane
hydrazine
Furaldehyde
Bromine
Cyclization
Succinic Acid
Gram-Negative Bacteria
Acetic Acid
Bacteria
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

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abstract = "The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2- bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 μg/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",
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Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4- oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes. / Holla, B. Shivararna; Gonsalves, Richard; Shenoy, Shalini.

In: European Journal of Medicinal Chemistry, Vol. 35, No. 2, 01.01.2000, p. 267-271.

Research output: Contribution to journalArticle

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AB - The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2- bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 μg/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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