Synthesis and anti‐inflammatory activity of 3‐(benzylideneamino)coumarins in rodents

V. Maddi, K.S. Raghu, M.N.A. Rao

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A series of substituted 3‐(benzylideneamino)coumarins was synthesized and evaluated for anti‐inflammatory activity against carrageenan‐induced edema in rats. Halogenated derivatives 4g and 4c, at oral doses of 100 mg/kg, showed 75 and 60% antiedematous activity, respectively (phenylbutazone antiedematous activity, 58%). The analgesic activity of 4g and 4c, based on inhibition of acetic acid‐induced writhing in mice (67 and 62%, respectively, at oral doses of 100 mg/kg) was comparable with that of aspirin (58%). However, these derivatives were devoid of antipyretic activity and showed low activity against adjuvant‐induced arthritis. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
Original languageUndefined/Unknown
Pages (from-to)964-966
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume81
Issue number9
DOIs
Publication statusPublished - 1992
Externally publishedYes

Cite this

Maddi, V. ; Raghu, K.S. ; Rao, M.N.A. / Synthesis and anti‐inflammatory activity of 3‐(benzylideneamino)coumarins in rodents. In: Journal of Pharmaceutical Sciences. 1992 ; Vol. 81, No. 9. pp. 964-966.
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Synthesis and anti‐inflammatory activity of 3‐(benzylideneamino)coumarins in rodents. / Maddi, V.; Raghu, K.S.; Rao, M.N.A.

In: Journal of Pharmaceutical Sciences, Vol. 81, No. 9, 1992, p. 964-966.

Research output: Contribution to journalArticle

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AU - Maddi, V.

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PY - 1992

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