Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones and of 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones

K. Satyanarayana, M.N.A. Rao

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Two series of styrylcarbonyl 3‐phenylsydnone derivatives, 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones (series I, 1–21) and 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones (series II, 22–40), were synthesized and evaluated pharmacologically at a dose of 100 mg/kg po. Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan‐induced edema and acetic acid‐induced writhing assays, respectively. Compound 35 in the latter assay showed activity somewhat similar to that of the positive control drug, aspirin, administered at the same dosage. Compounds 11, 17, and 23 showed activity in both assays, and 23 also was active in the adjuvant‐induced arthritis assay. Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company
Original languageUndefined/Unknown
Pages (from-to)263-266
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume84
Issue number2
DOIs
Publication statusPublished - 1995

Cite this

@article{a600a7b1802d47b7a9736f60d61db77f,
title = "Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones and of 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones",
abstract = "Two series of styrylcarbonyl 3‐phenylsydnone derivatives, 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones (series I, 1–21) and 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones (series II, 22–40), were synthesized and evaluated pharmacologically at a dose of 100 mg/kg po. Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan‐induced edema and acetic acid‐induced writhing assays, respectively. Compound 35 in the latter assay showed activity somewhat similar to that of the positive control drug, aspirin, administered at the same dosage. Compounds 11, 17, and 23 showed activity in both assays, and 23 also was active in the adjuvant‐induced arthritis assay. Copyright {\circledC} 1995 Wiley‐Liss, Inc., A Wiley Company",
author = "K. Satyanarayana and M.N.A. Rao",
note = "cited By 52",
year = "1995",
doi = "10.1002/jps.2600840228",
language = "Undefined/Unknown",
volume = "84",
pages = "263--266",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
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TY - JOUR

T1 - Synthesis and antiinflammatory, analgesic, and antipyretic testing of 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones and of 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones

AU - Satyanarayana, K.

AU - Rao, M.N.A.

N1 - cited By 52

PY - 1995

Y1 - 1995

N2 - Two series of styrylcarbonyl 3‐phenylsydnone derivatives, 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones (series I, 1–21) and 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones (series II, 22–40), were synthesized and evaluated pharmacologically at a dose of 100 mg/kg po. Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan‐induced edema and acetic acid‐induced writhing assays, respectively. Compound 35 in the latter assay showed activity somewhat similar to that of the positive control drug, aspirin, administered at the same dosage. Compounds 11, 17, and 23 showed activity in both assays, and 23 also was active in the adjuvant‐induced arthritis assay. Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company

AB - Two series of styrylcarbonyl 3‐phenylsydnone derivatives, 4‐[1‐oxo‐(3‐substituted aryl)‐2‐propenyl]‐3‐phenylsydnones (series I, 1–21) and 3‐[4‐[3‐(substituted aryl)‐1‐oxo‐2‐propenyl]phenyl]sydnones (series II, 22–40), were synthesized and evaluated pharmacologically at a dose of 100 mg/kg po. Eleven compounds in series I plus one in series II and six in series I plus seven in series II were active in the carrageenan‐induced edema and acetic acid‐induced writhing assays, respectively. Compound 35 in the latter assay showed activity somewhat similar to that of the positive control drug, aspirin, administered at the same dosage. Compounds 11, 17, and 23 showed activity in both assays, and 23 also was active in the adjuvant‐induced arthritis assay. Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company

U2 - 10.1002/jps.2600840228

DO - 10.1002/jps.2600840228

M3 - Article

VL - 84

SP - 263

EP - 266

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 2

ER -