Synthesis and antimicrobial activities of 1,3,5 trisubstituted 2-pyrazolines

G. Gautham Shenoy, A.R. Bhat, G. Varadaraj Bhat, M. Kotian

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A series of new 1,3,5-trisubstituted 2-pyrazolines have been synthesized and evaluated for antitubercular, antibacterial and antifungal activity in-vitro. Some of the compounds exhibited antitubercular activity at 1μg/ml concentration level. However, none of the compounds exhibited antibacterial/antifungal activity.
Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume10
Issue number3
Publication statusPublished - 2001

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@article{61b3cf9197084a0997d1abc21f3f20f4,
title = "Synthesis and antimicrobial activities of 1,3,5 trisubstituted 2-pyrazolines",
abstract = "A series of new 1,3,5-trisubstituted 2-pyrazolines have been synthesized and evaluated for antitubercular, antibacterial and antifungal activity in-vitro. Some of the compounds exhibited antitubercular activity at 1μg/ml concentration level. However, none of the compounds exhibited antibacterial/antifungal activity.",
author = "{Gautham Shenoy}, G. and A.R. Bhat and {Varadaraj Bhat}, G. and M. Kotian",
note = "Cited By :14 Export Date: 10 November 2017 Correspondence Address: Gautham Shenoy, G.; College of Pharmaceutical Sciences, Manipal-576 119, India References: Nauduri, D., Reddy, G.B., (1998) Chem. Pharm. Bull. Tokyo, 46 (8), p. 1254; Korgaokar, S.S., Patil, P.H., Shah, M.T., Parekh, H.H., (1996) Indian J. Pharm. Sci., 58, p. 222; Udupi, R.H., Kushnoor, A.R., Bhat, A.R., (1998) Indian J. Heterocyclic Chem., 8, p. 63; Bilgin, A.A., Palaska, E., Sunal, R., (1993) Arzneimforsch. Drug Res., 43, p. 1041; Bhat, A.R., Rao, S.N., Udupi, R.H., (1998) Indian J. Heterocyclic Chem., 7, p. 217; Gopalan Kutty, N., (1990) Studies in the Synthesis and Biological Activities of Compounds of Medicinal Importance : Heterocylic Prostanoids Thiazolidinones, Pyrazolines and Related Compounds, pp. 1176-1179. , Ph.D. thesis submitted to Mangalore University; Udupi, R.H., (1995) Studies on the Synthesis of Substituted Azetidinones, Quinazolinones and Related Compounds for Possible Antitubercular Activity and Other Pharmacological Profiles, pp. 233-234. , Ph.D. Thesis submitted to Mangalore University; Cruickshank, R., Duguid, J.P., Marmion, B.P., Swain, R.H.A., (1975) Medical Microbiology, 12th Ed., 2, p. 204. , Churchill Livingstone; Stockes, E.J., Ridgeway, G.L., (1975) Clinical Bacteriology, 5th Ed, p. 215. , Edward Arnold Ltd; Colleu, J.G., Fraser, A.G., Marmion, B.P., Simons, A., (1996) Mackei Mc Cartney-Practical Medical Microbiology 14th Ed., p. 715. , Churchill Livingstone, London",
year = "2001",
language = "English",
volume = "10",
pages = "197--200",
journal = "Indian Journal of Heterocyclic Chemistry",
issn = "0971-1627",
publisher = "National Academy of Chemistry",
number = "3",

}

Synthesis and antimicrobial activities of 1,3,5 trisubstituted 2-pyrazolines. / Gautham Shenoy, G.; Bhat, A.R.; Varadaraj Bhat, G.; Kotian, M.

In: Indian Journal of Heterocyclic Chemistry, Vol. 10, No. 3, 2001, p. 197-200.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and antimicrobial activities of 1,3,5 trisubstituted 2-pyrazolines

AU - Gautham Shenoy, G.

AU - Bhat, A.R.

AU - Varadaraj Bhat, G.

AU - Kotian, M.

N1 - Cited By :14 Export Date: 10 November 2017 Correspondence Address: Gautham Shenoy, G.; College of Pharmaceutical Sciences, Manipal-576 119, India References: Nauduri, D., Reddy, G.B., (1998) Chem. Pharm. Bull. Tokyo, 46 (8), p. 1254; Korgaokar, S.S., Patil, P.H., Shah, M.T., Parekh, H.H., (1996) Indian J. Pharm. Sci., 58, p. 222; Udupi, R.H., Kushnoor, A.R., Bhat, A.R., (1998) Indian J. Heterocyclic Chem., 8, p. 63; Bilgin, A.A., Palaska, E., Sunal, R., (1993) Arzneimforsch. Drug Res., 43, p. 1041; Bhat, A.R., Rao, S.N., Udupi, R.H., (1998) Indian J. Heterocyclic Chem., 7, p. 217; Gopalan Kutty, N., (1990) Studies in the Synthesis and Biological Activities of Compounds of Medicinal Importance : Heterocylic Prostanoids Thiazolidinones, Pyrazolines and Related Compounds, pp. 1176-1179. , Ph.D. thesis submitted to Mangalore University; Udupi, R.H., (1995) Studies on the Synthesis of Substituted Azetidinones, Quinazolinones and Related Compounds for Possible Antitubercular Activity and Other Pharmacological Profiles, pp. 233-234. , Ph.D. Thesis submitted to Mangalore University; Cruickshank, R., Duguid, J.P., Marmion, B.P., Swain, R.H.A., (1975) Medical Microbiology, 12th Ed., 2, p. 204. , Churchill Livingstone; Stockes, E.J., Ridgeway, G.L., (1975) Clinical Bacteriology, 5th Ed, p. 215. , Edward Arnold Ltd; Colleu, J.G., Fraser, A.G., Marmion, B.P., Simons, A., (1996) Mackei Mc Cartney-Practical Medical Microbiology 14th Ed., p. 715. , Churchill Livingstone, London

PY - 2001

Y1 - 2001

N2 - A series of new 1,3,5-trisubstituted 2-pyrazolines have been synthesized and evaluated for antitubercular, antibacterial and antifungal activity in-vitro. Some of the compounds exhibited antitubercular activity at 1μg/ml concentration level. However, none of the compounds exhibited antibacterial/antifungal activity.

AB - A series of new 1,3,5-trisubstituted 2-pyrazolines have been synthesized and evaluated for antitubercular, antibacterial and antifungal activity in-vitro. Some of the compounds exhibited antitubercular activity at 1μg/ml concentration level. However, none of the compounds exhibited antibacterial/antifungal activity.

M3 - Article

VL - 10

SP - 197

EP - 200

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

SN - 0971-1627

IS - 3

ER -