Synthesis and antimicrobial activities of some ethyl 2-arylthio-6- arylimidazo[2,1-b]thiazole-3-carboxylates and their sulfones

Nitinkumar S. Shetty, Rajesh S. Koti, Ravi S. Lamani, Naveenkumar P. Badiger, I. A M Khazi

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A series of new 2-arylthio-3-ethoxycarbonyl-6-arylimidazo[2,1-b]thiazoles (4a-4h) and 2-arenesulfonyl-3-ethoxycarbonyl-6-arylimidazo[2,1-b]thiazoles (5a-5h) have been prepared and characterized by analytical and spectral methods. The title compounds 4a-4h and 5a-5h were obtained by the reaction of 2-amino-4-ethoxycarbonyl-5-arylthiothiazoles (2a and 2b)/2-amino-4- ethoxycarbonyl-5-arenesulphonyl-thiazoles (3a and 3b) with various phenacyl bromides in anhydrous ethanol. These newly synthesized compounds (4a-4h and 5a-5h) were screened for their antibacterial activity against Gram-negative bacterium Escherichia coli, Gram-positive bacterium Staphylococcus aureus, and antifungal properties against Aspergillus niger and Candida albicans.

Original languageEnglish
Pages (from-to)539-547
Number of pages9
JournalJournal of Sulfur Chemistry
Issue number5
Publication statusPublished - 10-2008


All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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