Synthesis and antimicrobial activity of N1-(arylidine hydrazidomethyl)-indoles, 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines and 5-benzylidine derivatives of thiazolidinones

Several N1-(arylidine hydrazidomethyl)-indoles were prepared by condensing N1-indolyl acetyl hydrazine with different substituted benzaldehydes. 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines were prepared by condensing N 1-(arylidine hydrazidomethyl)-indoles with mercaptoacetic acid followed by the Knoevanagel condensation with benzaldehyde leading to the 5-benzylidine derivatives. The IR, 1HNMR and mass spectral studies confirmed the structures of these compounds. The synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Proteus vulgaris, Candida albicans and Aspergillus niger. The zones of inhibition were compared with the standard drugs under the identical conditions.