Synthesis and antimicrobial activity of N1-(arylidine hydrazidomethyl)-indoles, 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines and 5-benzylidine derivatives of thiazolidinones

V. Lather, P.V.R. Chowdary

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Several N1-(arylidine hydrazidomethyl)-indoles were prepared by condensing N1-indolyl acetyl hydrazine with different substituted benzaldehydes. 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines were prepared by condensing N 1-(arylidine hydrazidomethyl)-indoles with mercaptoacetic acid followed by the Knoevanagel condensation with benzaldehyde leading to the 5-benzylidine derivatives. The IR, 1HNMR and mass spectral studies confirmed the structures of these compounds. The synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Proteus vulgaris, Candida albicans and Aspergillus niger. The zones of inhibition were compared with the standard drugs under the identical conditions.
Original languageEnglish
Pages (from-to)576-579
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume65
Issue number6
Publication statusPublished - 2003

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Thiazolidines
Indoles
hydrazine
Benzaldehydes
Proteus vulgaris
Salmonella typhi
Aspergillus niger
Bacillus subtilis
Candida albicans
Pseudomonas aeruginosa
Staphylococcus aureus
Escherichia coli
Pharmaceutical Preparations
benzaldehyde
2-mercaptoacetate
In Vitro Techniques

Cite this

@article{87db6dff3d8e49d7bcac875f78e31abe,
title = "Synthesis and antimicrobial activity of N1-(arylidine hydrazidomethyl)-indoles, 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines and 5-benzylidine derivatives of thiazolidinones",
abstract = "Several N1-(arylidine hydrazidomethyl)-indoles were prepared by condensing N1-indolyl acetyl hydrazine with different substituted benzaldehydes. 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines were prepared by condensing N 1-(arylidine hydrazidomethyl)-indoles with mercaptoacetic acid followed by the Knoevanagel condensation with benzaldehyde leading to the 5-benzylidine derivatives. The IR, 1HNMR and mass spectral studies confirmed the structures of these compounds. The synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Proteus vulgaris, Candida albicans and Aspergillus niger. The zones of inhibition were compared with the standard drugs under the identical conditions.",
author = "V. Lather and P.V.R. Chowdary",
note = "Cited By :11 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Lather, V.; Department of Pharmaceutical Sciences, M. D. University, Rohtak-124001, India; email: vinnylather@yahoo.com References: Gadaginamath, G.S., Shyadligeri, A.S., Kavali, R.R., (1999) Indian J. Chem, 38 B, p. 156; Renukadevi, P., Biradar, J.S., (1999) Indian J. Heterocycl. Chem, 9, p. 107; Hogle, M.B., Uthale, A.C., Nikam, B.P., (1991) Indian J. Chem, 30 B, p. 717; Hogle, M.B., Uthale, A.C., (1990) Indian J. Chem, 29 B, p. 590; Oza, H., Joshi, D., Parekh, H., (1998) Indian J. Chem, 37 (B), p. 822; Lodhi, R.S., Srivatava, S.D., (1997) Indian J. Chem, 36 B, p. 947; Desai, N.C., Dave, D., Shah, M.D., Vyas, G.D., (2000) Indian J. Chem, 39 B, p. 277; Dutta, M.M., Goswami, B.N., Kataky, J.C.S., (1990) J. Indian Chem. Soc, 67, p. 322; Kansagra, B.P., Bhatt, H.H., Parikh, A.R., (2000) Indian J. Heterocycl. Chem, 10, p. 1; Mishra, S., Srivastava, S.K., Srivastava, S.D., (1997) Indian J. Chem, 36 B, p. 826; Mulwad, V.V., Shirodkar, J.M., (2002) Indian J. Heterocycl. Chem, 11, p. 199; Diufno, M.V., Mazzoni, O., Piscopo, E., Calignano, A., Giordano, F., Bolognese, A., (1992) J. Med. Chem, 35, p. 2910",
year = "2003",
language = "English",
volume = "65",
pages = "576--579",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "6",

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TY - JOUR

T1 - Synthesis and antimicrobial activity of N1-(arylidine hydrazidomethyl)-indoles, 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines and 5-benzylidine derivatives of thiazolidinones

AU - Lather, V.

AU - Chowdary, P.V.R.

N1 - Cited By :11 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Lather, V.; Department of Pharmaceutical Sciences, M. D. University, Rohtak-124001, India; email: vinnylather@yahoo.com References: Gadaginamath, G.S., Shyadligeri, A.S., Kavali, R.R., (1999) Indian J. Chem, 38 B, p. 156; Renukadevi, P., Biradar, J.S., (1999) Indian J. Heterocycl. Chem, 9, p. 107; Hogle, M.B., Uthale, A.C., Nikam, B.P., (1991) Indian J. Chem, 30 B, p. 717; Hogle, M.B., Uthale, A.C., (1990) Indian J. Chem, 29 B, p. 590; Oza, H., Joshi, D., Parekh, H., (1998) Indian J. Chem, 37 (B), p. 822; Lodhi, R.S., Srivatava, S.D., (1997) Indian J. Chem, 36 B, p. 947; Desai, N.C., Dave, D., Shah, M.D., Vyas, G.D., (2000) Indian J. Chem, 39 B, p. 277; Dutta, M.M., Goswami, B.N., Kataky, J.C.S., (1990) J. Indian Chem. Soc, 67, p. 322; Kansagra, B.P., Bhatt, H.H., Parikh, A.R., (2000) Indian J. Heterocycl. Chem, 10, p. 1; Mishra, S., Srivastava, S.K., Srivastava, S.D., (1997) Indian J. Chem, 36 B, p. 826; Mulwad, V.V., Shirodkar, J.M., (2002) Indian J. Heterocycl. Chem, 11, p. 199; Diufno, M.V., Mazzoni, O., Piscopo, E., Calignano, A., Giordano, F., Bolognese, A., (1992) J. Med. Chem, 35, p. 2910

PY - 2003

Y1 - 2003

N2 - Several N1-(arylidine hydrazidomethyl)-indoles were prepared by condensing N1-indolyl acetyl hydrazine with different substituted benzaldehydes. 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines were prepared by condensing N 1-(arylidine hydrazidomethyl)-indoles with mercaptoacetic acid followed by the Knoevanagel condensation with benzaldehyde leading to the 5-benzylidine derivatives. The IR, 1HNMR and mass spectral studies confirmed the structures of these compounds. The synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Proteus vulgaris, Candida albicans and Aspergillus niger. The zones of inhibition were compared with the standard drugs under the identical conditions.

AB - Several N1-(arylidine hydrazidomethyl)-indoles were prepared by condensing N1-indolyl acetyl hydrazine with different substituted benzaldehydes. 2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines were prepared by condensing N 1-(arylidine hydrazidomethyl)-indoles with mercaptoacetic acid followed by the Knoevanagel condensation with benzaldehyde leading to the 5-benzylidine derivatives. The IR, 1HNMR and mass spectral studies confirmed the structures of these compounds. The synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Proteus vulgaris, Candida albicans and Aspergillus niger. The zones of inhibition were compared with the standard drugs under the identical conditions.

M3 - Article

VL - 65

SP - 576

EP - 579

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 6

ER -