Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles

S.G. Kini, A.R. Bhat, R. Bhat, N. Narayanaswamy

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2 Citations (Scopus)

Abstract

New 3,5 disubstituted isoxazoles were prepared by the action of hydroxylamine hydrochloride and sodium acetate on 3-{3-[3-(trifluoromethyl) phenoxy/phenoxy]-4-substituted phenyl/phenyl}-1-(4-substitutedphenyl)-2-propene- 1-ones (chalcones) (II). The structures of the synthesized compounds were settled on the basis of spectral data. The antibacterial, antitubercular and antifungal activities of all compounds have been evaluated. Compounds carrying halogen on a-ring showed strong antimicrobial activity. However the titled compounds exhibited moderate antifungal activity. Some compounds exhibited significant activity towards a strain of Mycobacterium tuberculosis H 37Rv.
Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume17
Issue number4
Publication statusPublished - 2008

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