Synthesis and antimicrobial activity of some novel thienopyrimidines and triazolothienopyrimidines

Nitinkumar S. Shetty, Ravi S. Lamani, Imtiyaz Ahmed M Khazi

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1- benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalJournal of Chemical Sciences
Volume121
Issue number3
Publication statusPublished - 05-2009

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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