Synthesis and antimicrobial activity of some novel thienopyrimidines and triazolothienopyrimidines

Nitinkumar S. Shetty, Ravi S. Lamani, Imtiyaz Ahmed M Khazi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1- benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalJournal of Chemical Sciences
Volume121
Issue number3
Publication statusPublished - 05-2009

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Triazoles
Bioactivity
thienopyrimidine
benzothiophene

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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abstract = "Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1- benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.",
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Synthesis and antimicrobial activity of some novel thienopyrimidines and triazolothienopyrimidines. / Shetty, Nitinkumar S.; Lamani, Ravi S.; Khazi, Imtiyaz Ahmed M.

In: Journal of Chemical Sciences, Vol. 121, No. 3, 05.2009, p. 301-307.

Research output: Contribution to journalArticle

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