Synthesis and antimicrobial screening of pyrimidine annulated dihydropyrano[2, 3-c] pyrazole derivatives

Hemant Hegde, Chuljin Ahn, Preeti Waribam, Nitinkumar S. Shetty

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction medium which facilitated improved yield compared to base catalyzed reaction. Wide scope of substrates, simple workup procedure and high yield even in the absence of catalyst are the major highlights of the protocol. Dihydropyrano[ 2, 3-c]pyrazoles on condensation with formic acid formed pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives. All the products are characterized using FTIR, 1H-NMR and 13C-NMR spectroscopic techniques. The molecules have shown good to moderate activity as antimicrobial agents when compared to the standard drug ciprofloxacin.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalJournal of the Korean Chemical Society
Volume62
Issue number2
DOIs
Publication statusPublished - 01-01-2018

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Screening
formic acid
Nuclear magnetic resonance
Derivatives
Antimicrobial agents
Catalysts
Formic acid
Pyrazoles
Polyethylene glycols
Condensation
Ciprofloxacin
Anti-Infective Agents
Molecules
Substrates
Pharmaceutical Preparations
pyrimidine
pyrazole
polyethylene glycol 400

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Chemical Engineering (miscellaneous)

Cite this

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abstract = "A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction medium which facilitated improved yield compared to base catalyzed reaction. Wide scope of substrates, simple workup procedure and high yield even in the absence of catalyst are the major highlights of the protocol. Dihydropyrano[ 2, 3-c]pyrazoles on condensation with formic acid formed pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives. All the products are characterized using FTIR, 1H-NMR and 13C-NMR spectroscopic techniques. The molecules have shown good to moderate activity as antimicrobial agents when compared to the standard drug ciprofloxacin.",
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Synthesis and antimicrobial screening of pyrimidine annulated dihydropyrano[2, 3-c] pyrazole derivatives. / Hegde, Hemant; Ahn, Chuljin; Waribam, Preeti; Shetty, Nitinkumar S.

In: Journal of the Korean Chemical Society, Vol. 62, No. 2, 01.01.2018, p. 87-92.

Research output: Contribution to journalArticle

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T1 - Synthesis and antimicrobial screening of pyrimidine annulated dihydropyrano[2, 3-c] pyrazole derivatives

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AB - A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction medium which facilitated improved yield compared to base catalyzed reaction. Wide scope of substrates, simple workup procedure and high yield even in the absence of catalyst are the major highlights of the protocol. Dihydropyrano[ 2, 3-c]pyrazoles on condensation with formic acid formed pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives. All the products are characterized using FTIR, 1H-NMR and 13C-NMR spectroscopic techniques. The molecules have shown good to moderate activity as antimicrobial agents when compared to the standard drug ciprofloxacin.

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