Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones

P. Nandy, M.T. Vishalakshi, A.R. Bhat

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.
Original languageEnglish
Pages (from-to)293-294
Number of pages2
JournalIndian Journal of Heterocyclic Chemistry
Volume15
Issue number3
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Mannich Bases
Spectrum analysis
Formaldehyde
Condensation
Chemical analysis
4-hydroxyquinazoline

Cite this

Nandy, P. ; Vishalakshi, M.T. ; Bhat, A.R. / Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones. In: Indian Journal of Heterocyclic Chemistry. 2006 ; Vol. 15, No. 3. pp. 293-294.
@article{851c951db6c04f6c92cdf9a74233341a,
title = "Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones",
abstract = "Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.",
author = "P. Nandy and M.T. Vishalakshi and A.R. Bhat",
note = "Cited By :35 Export Date: 10 November 2017 Correspondence Address: Vishalakshi, M.T.; Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal-576 119, India References: Shukla, J.S., Agarwal, V.K., (1985) Indian J. Chem., 24, p. 886; Sengupta, A.K., Gupta, M.M., (1982) Indian J. Chem., 21 B, p. 600; Waisser, K., Gregor, J., Dostal, H., Kune, J., Kubicova, L., Klimeova, V., Kaustova, J., (2001) IL Farmaco, 56 (10), p. 803; Kune, J., Baant, J., Pour, M., Waisser, K., Losarek, M., Janoth, J., (2000) IL Farmaco, 55 (11-12), p. 725; Paranjape, S.D., Bobade, A.S., Khadse, B.G., (2001) Drug. Res., 51 (11), p. 916; Watt, B., Rayner, A., Harris, G., (1996) Mackie & Mc Cartney Practical Medical Microbiology, p. 331. , Churchill Livigstone, New York",
year = "2006",
language = "English",
volume = "15",
pages = "293--294",
journal = "Indian Journal of Heterocyclic Chemistry",
issn = "0971-1627",
publisher = "National Academy of Chemistry",
number = "3",

}

Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones. / Nandy, P.; Vishalakshi, M.T.; Bhat, A.R.

In: Indian Journal of Heterocyclic Chemistry, Vol. 15, No. 3, 2006, p. 293-294.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones

AU - Nandy, P.

AU - Vishalakshi, M.T.

AU - Bhat, A.R.

N1 - Cited By :35 Export Date: 10 November 2017 Correspondence Address: Vishalakshi, M.T.; Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal-576 119, India References: Shukla, J.S., Agarwal, V.K., (1985) Indian J. Chem., 24, p. 886; Sengupta, A.K., Gupta, M.M., (1982) Indian J. Chem., 21 B, p. 600; Waisser, K., Gregor, J., Dostal, H., Kune, J., Kubicova, L., Klimeova, V., Kaustova, J., (2001) IL Farmaco, 56 (10), p. 803; Kune, J., Baant, J., Pour, M., Waisser, K., Losarek, M., Janoth, J., (2000) IL Farmaco, 55 (11-12), p. 725; Paranjape, S.D., Bobade, A.S., Khadse, B.G., (2001) Drug. Res., 51 (11), p. 916; Watt, B., Rayner, A., Harris, G., (1996) Mackie & Mc Cartney Practical Medical Microbiology, p. 331. , Churchill Livigstone, New York

PY - 2006

Y1 - 2006

N2 - Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.

AB - Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.

M3 - Article

VL - 15

SP - 293

EP - 294

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

SN - 0971-1627

IS - 3

ER -