4-Hydroxy benzaldehyde (1a) and vanillin (1b) were converted into respective aryloxy acetic acid derivatives (2a & 2b) by treating with chloroacetic acid, when (1 & 2) were heated with 3-fluoro-4-chloro aniline (3), Schiffs bases (4a-d) were obtained in good yields, (4a-d) when reacted with aryl and substituted aryloxy acetyl chlorides, 1,3-substituted-4-(4-hydroxy phenyl)-azetidin-2-ones (5a1-a8), 1,3-substituted-4-(3-methoxy-4-hydroxy phenyl)-azetidin-2-ones (5a9-a16), 1,3-substituted 4(4-carboxy methylene oxy phenyl)-azetidin-2-ones (5a17-a24) and 1,3-substituted-4-(3-methoxy 4-carboxy methylene oxy phenyl)-azetidin-2-ones (5a25-a32) were obtained. Some of the compounds showed promising antitubercular activity. Most of the compounds exhibited significant antibacterial and antifungal activities.
|Number of pages||6|
|Journal||Indian Journal of Heterocyclic Chemistry|
|Publication status||Published - 1997|
Udupi, R. H., Mayur, Y. C., & Bhat, A. R. (1997). Synthesis and biological activity of certain azetidin-2-ones. Indian Journal of Heterocyclic Chemistry, 6(4), 281-286. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031507235&partnerID=40&md5=47f50ab98d8ec044f27d3f8962a49340