Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

Mari Sithambaram Karthikeyan, Dasappa Jagadeesh Prasad, Boja Poojary, K. Subrahmanya Bhat, Bantwal Shivarama Holla, Nalilu Suchetha Kumari

Research output: Contribution to journalArticle

425 Citations (Scopus)

Abstract

A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

Original languageEnglish
Pages (from-to)7482-7489
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number22
DOIs
Publication statusPublished - 15-11-2006

Fingerprint

Bearings (structural)
Mannich Bases
Triazoles
Schiff Bases
Bioactivity
Formaldehyde
Amines

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Karthikeyan, Mari Sithambaram ; Prasad, Dasappa Jagadeesh ; Poojary, Boja ; Subrahmanya Bhat, K. ; Holla, Bantwal Shivarama ; Kumari, Nalilu Suchetha. / Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety. In: Bioorganic and Medicinal Chemistry. 2006 ; Vol. 14, No. 22. pp. 7482-7489.
@article{e6d5d1cd77644604ab75770ba3f438dd,
title = "Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety",
abstract = "A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.",
author = "Karthikeyan, {Mari Sithambaram} and Prasad, {Dasappa Jagadeesh} and Boja Poojary and {Subrahmanya Bhat}, K. and Holla, {Bantwal Shivarama} and Kumari, {Nalilu Suchetha}",
year = "2006",
month = "11",
day = "15",
doi = "10.1016/j.bmc.2006.07.015",
language = "English",
volume = "14",
pages = "7482--7489",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ireland Ltd",
number = "22",

}

Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety. / Karthikeyan, Mari Sithambaram; Prasad, Dasappa Jagadeesh; Poojary, Boja; Subrahmanya Bhat, K.; Holla, Bantwal Shivarama; Kumari, Nalilu Suchetha.

In: Bioorganic and Medicinal Chemistry, Vol. 14, No. 22, 15.11.2006, p. 7482-7489.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

AU - Karthikeyan, Mari Sithambaram

AU - Prasad, Dasappa Jagadeesh

AU - Poojary, Boja

AU - Subrahmanya Bhat, K.

AU - Holla, Bantwal Shivarama

AU - Kumari, Nalilu Suchetha

PY - 2006/11/15

Y1 - 2006/11/15

N2 - A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

AB - A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

UR - http://www.scopus.com/inward/record.url?scp=33749238697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749238697&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2006.07.015

DO - 10.1016/j.bmc.2006.07.015

M3 - Article

VL - 14

SP - 7482

EP - 7489

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 22

ER -