Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

Mari Sithambaram Karthikeyan; Dasappa Jagadeesh Prasad; Boja Poojary; K. Subrahmanya Bhat; Bantwal Shivarama Holla; Nalilu Suchetha Kumari

doi:10.1016/j.bmc.2006.07.015

Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

Mari Sithambaram Karthikeyan, Dasappa Jagadeesh Prasad, Boja Poojary, K. Subrahmanya Bhat, Bantwal Shivarama Holla, Nalilu Suchetha Kumari

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

510 Citations (Scopus)

Abstract

A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

Original language	English
Pages (from-to)	7482-7489
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	22
DOIs	https://doi.org/10.1016/j.bmc.2006.07.015
Publication status	Published - 15-11-2006

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2006.07.015

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title = "Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety",

abstract = "A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.",

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AU - Karthikeyan, Mari Sithambaram

AU - Prasad, Dasappa Jagadeesh

AU - Poojary, Boja

AU - Subrahmanya Bhat, K.

AU - Holla, Bantwal Shivarama

AU - Kumari, Nalilu Suchetha

PY - 2006/11/15

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AB - A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

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IS - 22

ER -

Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

Abstract

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