Synthesis and biological activity of some quinazolinone derivatives

R.H. Udupi, B. Ramesh, A.R. Bhat

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

N-acetyl-4-nitro anthranilic acid (III), was heated with formamide at 180° for 4 hr, when 7-nitro-2-methyl-4 (3H)-quinazolinone (IV) was obtained in good yields. Mannich bases (Va-o) were obtained when (IV) was reacted with certain amines and other compounds in the presence of formaldehyde under Mannich conditions. The compounds synthesized were screened for antibacterial and some of them for antitubercular activities against S. aureus, B-subtilis (+ve), E. coli. S. typhae, P. Vulgaris (-ve) and human strain of Mycobacterium tuberculosis H37Rv. Four compounds were screened for antiinflammatory activity. Some of the compounds showed promising activities.
Original languageUndefined/Unknown
Pages (from-to)301-304
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume8
Issue number4
Publication statusPublished - 1999

Cite this

Udupi, R.H. ; Ramesh, B. ; Bhat, A.R. / Synthesis and biological activity of some quinazolinone derivatives. In: Indian Journal of Heterocyclic Chemistry. 1999 ; Vol. 8, No. 4. pp. 301-304.
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Synthesis and biological activity of some quinazolinone derivatives. / Udupi, R.H.; Ramesh, B.; Bhat, A.R.

In: Indian Journal of Heterocyclic Chemistry, Vol. 8, No. 4, 1999, p. 301-304.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological activity of some quinazolinone derivatives

AU - Udupi, R.H.

AU - Ramesh, B.

AU - Bhat, A.R.

N1 - cited By 5

PY - 1999

Y1 - 1999

N2 - N-acetyl-4-nitro anthranilic acid (III), was heated with formamide at 180° for 4 hr, when 7-nitro-2-methyl-4 (3H)-quinazolinone (IV) was obtained in good yields. Mannich bases (Va-o) were obtained when (IV) was reacted with certain amines and other compounds in the presence of formaldehyde under Mannich conditions. The compounds synthesized were screened for antibacterial and some of them for antitubercular activities against S. aureus, B-subtilis (+ve), E. coli. S. typhae, P. Vulgaris (-ve) and human strain of Mycobacterium tuberculosis H37Rv. Four compounds were screened for antiinflammatory activity. Some of the compounds showed promising activities.

AB - N-acetyl-4-nitro anthranilic acid (III), was heated with formamide at 180° for 4 hr, when 7-nitro-2-methyl-4 (3H)-quinazolinone (IV) was obtained in good yields. Mannich bases (Va-o) were obtained when (IV) was reacted with certain amines and other compounds in the presence of formaldehyde under Mannich conditions. The compounds synthesized were screened for antibacterial and some of them for antitubercular activities against S. aureus, B-subtilis (+ve), E. coli. S. typhae, P. Vulgaris (-ve) and human strain of Mycobacterium tuberculosis H37Rv. Four compounds were screened for antiinflammatory activity. Some of the compounds showed promising activities.

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JF - Indian Journal of Heterocyclic Chemistry

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