Synthesis and biological evaluation of 1,3,5-trisubstituted pyrazolines bearing benzofuran

V. Harinadha Babu, S.K. Manna, Sneha Surendran, K.K. Srinivasan, G. Varadaraj Bhat

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Abstract

Cyclocondensation of benzofuran chalcones (2) with Norfloxacin and Mefenamic acid hydrazides resulted in the formation of benzofuran 2-pyrazolines (3,4). Chalcones (2) were synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.
Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume13
Issue number3
Publication statusPublished - 2004

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