Synthesis and biological evaluation of 2-phenyl chromen-4-ones for their antioxidant and antimicrobial activity

K. K. Srinivasan, Amit Goomber, Suthar Sharad Kumar, Angel Treasa Thomas, Alex Joseph

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Claisen-Schmidt condensation reaction of aldehydes and ketones afforded intermediate chalcones, which were cyclized into final products as substituted 2- phenyl chromen-4-ones. The synthesized compounds were characterized by physicochemical and spectral studies. All the synthesized eight compounds were screened for antioxidant activity by DPPH radical scavenging assay method and antibacterial activity against S. aureus, B. subtilis (gram +ve), P. aeruginosa, E. coli, (gram –ve) and antifungal activity against C. albicans and A. niger. All the synthesized compounds have shown moderate antioxidant activity while the compounds AFLV-4, -7, -8 exhibited considerable antimicrobial activity.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
Publication statusPublished - 2010


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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