Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones

P.V.R. Chowdary, S.G. Jawarkar, K. Shashikala Rani, G. Rao, V. Prasad

Research output: Contribution to journal › Article

Abstract

Various 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2- azetidinones were prepared by condensing N-(arylidine hydrazidomethyl)-indoles with chloroacetyl chloride. Their structures were established by chemical tests, IR and 1HNMR spectral data. These synthesized compounds were tested for their antibacterial, antifungal, antitubercular and antiinflammatory activities.
Original languageEnglish
Pages (from-to)610-614
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume67
Issue number5
Publication statusPublished - 2005
Externally publishedYes

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Indoles
Anti-Inflammatory Agents
chloroacetyl chloride
2-azetidinone

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Chowdary, P. V. R., Jawarkar, S. G., Shashikala Rani, K., Rao, G., & Prasad, V. (2005). Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones. Indian Journal of Pharmaceutical Sciences, 67(5), 610-614.
Chowdary, P.V.R. ; Jawarkar, S.G. ; Shashikala Rani, K. ; Rao, G. ; Prasad, V. / Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones. In: Indian Journal of Pharmaceutical Sciences. 2005 ; Vol. 67, No. 5. pp. 610-614.
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abstract = "Various 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2- azetidinones were prepared by condensing N-(arylidine hydrazidomethyl)-indoles with chloroacetyl chloride. Their structures were established by chemical tests, IR and 1HNMR spectral data. These synthesized compounds were tested for their antibacterial, antifungal, antitubercular and antiinflammatory activities.",
author = "P.V.R. Chowdary and S.G. Jawarkar and {Shashikala Rani}, K. and G. Rao and V. Prasad",
note = "Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Chowdary, P. V. R.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: pvrchowdary2003@yahoo.co.in References: Lather, V., Chowdary, P.V.R., (2003) Indian J. Pharm. Sci, 65, p. 576; Shah, M., Parikh, K., Parekh, H., (1998) Indian J. Chem, 37 B, p. 73; Sharma, P., Mandroi, A., (1998) Indian J. Pharm. Sci, 60, p. 128; Hogle, M.B., Uthale, A.C., (1990) Indian J. Chem, 29 B, p. 590; Kagthara, P., Upadhyay, T., Doshi, R., Parekh, H.H., (2000) Indian J. Heterocycl. Chem, 10, p. 9; Vashi, B.S., Mehta, D.S., Shah, V.H., (1998) Indian J. Chem, 37 B, p. 73; Agarwal, R., Agarwal, C., Singh, C., Misra, V.S., (1995) Indian J. Chem, 28 B, p. 893; Sharma, S.D., Pandhi, S.B., (1990) J. Org. Chem, 55, p. 2196; Sharma, S.D., Kaur, V., Saluja, A., (1994) Indian J. Chem, 33 B, p. 624",
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Chowdary, PVR, Jawarkar, SG, Shashikala Rani, K, Rao, G & Prasad, V 2005, 'Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones', Indian Journal of Pharmaceutical Sciences, vol. 67, no. 5, pp. 610-614.

Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones. / Chowdary, P.V.R.; Jawarkar, S.G.; Shashikala Rani, K.; Rao, G.; Prasad, V.

In: Indian Journal of Pharmaceutical Sciences, Vol. 67, No. 5, 2005, p. 610-614.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones

AU - Chowdary, P.V.R.

AU - Jawarkar, S.G.

AU - Shashikala Rani, K.

AU - Rao, G.

AU - Prasad, V.

N1 - Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Chowdary, P. V. R.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: pvrchowdary2003@yahoo.co.in References: Lather, V., Chowdary, P.V.R., (2003) Indian J. Pharm. Sci, 65, p. 576; Shah, M., Parikh, K., Parekh, H., (1998) Indian J. Chem, 37 B, p. 73; Sharma, P., Mandroi, A., (1998) Indian J. Pharm. Sci, 60, p. 128; Hogle, M.B., Uthale, A.C., (1990) Indian J. Chem, 29 B, p. 590; Kagthara, P., Upadhyay, T., Doshi, R., Parekh, H.H., (2000) Indian J. Heterocycl. Chem, 10, p. 9; Vashi, B.S., Mehta, D.S., Shah, V.H., (1998) Indian J. Chem, 37 B, p. 73; Agarwal, R., Agarwal, C., Singh, C., Misra, V.S., (1995) Indian J. Chem, 28 B, p. 893; Sharma, S.D., Pandhi, S.B., (1990) J. Org. Chem, 55, p. 2196; Sharma, S.D., Kaur, V., Saluja, A., (1994) Indian J. Chem, 33 B, p. 624

PY - 2005

Y1 - 2005

N2 - Various 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2- azetidinones were prepared by condensing N-(arylidine hydrazidomethyl)-indoles with chloroacetyl chloride. Their structures were established by chemical tests, IR and 1HNMR spectral data. These synthesized compounds were tested for their antibacterial, antifungal, antitubercular and antiinflammatory activities.

AB - Various 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2- azetidinones were prepared by condensing N-(arylidine hydrazidomethyl)-indoles with chloroacetyl chloride. Their structures were established by chemical tests, IR and 1HNMR spectral data. These synthesized compounds were tested for their antibacterial, antifungal, antitubercular and antiinflammatory activities.

M3 - Article

VL - 67

SP - 610

EP - 614

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 5

ER -

Chowdary PVR, Jawarkar SG, Shashikala Rani K, Rao G, Prasad V. Synthesis and biological evaluation of 4-(substituted aryl)-1-(N-indolyl acetamidyl)-3-chloro-2-azetidinones. Indian Journal of Pharmaceutical Sciences. 2005;67(5):610-614.

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