Synthesis and biological evaluation of aminoketones

U. Sankappa Rai, Arun M. Isloor, Prakash Shetty, Nishitha Isloor, Shridhar Malladi, Hoong Kun Fun

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13 Citations (Scopus)

Abstract

A three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding β-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized β-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by single-crystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent.

Original languageEnglish
Pages (from-to)6090-6094
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number12
DOIs
Publication statusPublished - 01-12-2010

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Sankappa Rai, U., Isloor, A. M., Shetty, P., Isloor, N., Malladi, S., & Fun, H. K. (2010). Synthesis and biological evaluation of aminoketones. European Journal of Medicinal Chemistry, 45(12), 6090-6094. https://doi.org/10.1016/j.ejmech.2010.09.015