Synthesis and biological evaluation of benzofuran incorporated benzodiazepines

V. Harinadha Babu, A. Gupta, K.K. Srinivasan, K.S.R. Pai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Condensation of 2-acetyl benzofuran (1) with different aromatic aldehydes in alcoholic NaOH afforded different chalcones (2). Cyclocondensation of these chalcones with o-phenylenediamine gave benzofuran benzodiazepines (3). The synthesized compounds were evaluated for antimicrobial, sedative and hypnotic activities.
Original languageEnglish
Pages (from-to)267-268
Number of pages2
JournalIndian Journal of Heterocyclic Chemistry
Volume14
Issue number3
Publication statusPublished - 2005

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Chalcones
Benzodiazepines
Hypnotics and Sedatives
Aldehydes
Condensation
benzofuran
1-benzofuran
1,2-diaminobenzene

Cite this

Harinadha Babu, V. ; Gupta, A. ; Srinivasan, K.K. ; Pai, K.S.R. / Synthesis and biological evaluation of benzofuran incorporated benzodiazepines. In: Indian Journal of Heterocyclic Chemistry. 2005 ; Vol. 14, No. 3. pp. 267-268.
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abstract = "Condensation of 2-acetyl benzofuran (1) with different aromatic aldehydes in alcoholic NaOH afforded different chalcones (2). Cyclocondensation of these chalcones with o-phenylenediamine gave benzofuran benzodiazepines (3). The synthesized compounds were evaluated for antimicrobial, sedative and hypnotic activities.",
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note = "Cited By :6 Export Date: 10 November 2017 Correspondence Address: Harinadha Babu, V.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Mahe, Manipal-576 104, India References: (1994) Chem. Abstr., 120, pp. 323143q; (1986) Chem. Abstr., 104, p. 68700; (1988) Chem. Abstr., 109, p. 65205; (1970) Chem. Abstr, 72, p. 132813; Winter, C.A., Risley, G.A., Nuss, G.W., (1962) Proc. Soc. Exp. Bio. Med., 111, p. 544; Smith, Q.E., (1960) Pharmacol. Screening Tests, Progress in Med Chem., 1. , Butterworths, London",
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Synthesis and biological evaluation of benzofuran incorporated benzodiazepines. / Harinadha Babu, V.; Gupta, A.; Srinivasan, K.K.; Pai, K.S.R.

In: Indian Journal of Heterocyclic Chemistry, Vol. 14, No. 3, 2005, p. 267-268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological evaluation of benzofuran incorporated benzodiazepines

AU - Harinadha Babu, V.

AU - Gupta, A.

AU - Srinivasan, K.K.

AU - Pai, K.S.R.

N1 - Cited By :6 Export Date: 10 November 2017 Correspondence Address: Harinadha Babu, V.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Mahe, Manipal-576 104, India References: (1994) Chem. Abstr., 120, pp. 323143q; (1986) Chem. Abstr., 104, p. 68700; (1988) Chem. Abstr., 109, p. 65205; (1970) Chem. Abstr, 72, p. 132813; Winter, C.A., Risley, G.A., Nuss, G.W., (1962) Proc. Soc. Exp. Bio. Med., 111, p. 544; Smith, Q.E., (1960) Pharmacol. Screening Tests, Progress in Med Chem., 1. , Butterworths, London

PY - 2005

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AB - Condensation of 2-acetyl benzofuran (1) with different aromatic aldehydes in alcoholic NaOH afforded different chalcones (2). Cyclocondensation of these chalcones with o-phenylenediamine gave benzofuran benzodiazepines (3). The synthesized compounds were evaluated for antimicrobial, sedative and hypnotic activities.

M3 - Article

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JF - Indian Journal of Heterocyclic Chemistry

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