Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents

K. Manna, Y.K. Agarwal, K.K. Srinivasan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.
Original languageEnglish
Pages (from-to)87-88
Number of pages2
JournalIndian Journal of Heterocyclic Chemistry
Volume18
Issue number1
Publication statusPublished - 2008

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Antitubercular Agents
Isoxazoles
Antifungal Agents
Chalcones
Anti-Bacterial Agents
Sodium Acetate
Hydroxylamine
Aldehydes
Anti-Inflammatory Agents
Nuclear magnetic resonance
benzofuran
1-benzofuran

Cite this

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title = "Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents",
abstract = "Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.",
author = "K. Manna and Y.K. Agarwal and K.K. Srinivasan",
note = "Cited By :4 Export Date: 10 November 2017 Correspondence Address: Manna, K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad, India References: Zboinska, E., Sztajer, H., Lejezak, B., Kafarski, P., (1990) FEMS Microbiol. Lett, 70, p. 23; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Rescifina, A., Chiacchio, M.A., Corsaro, A., De Clercq, E., lannazzo, D., Mastino, A., Piperno, A., Valveri, V., (2006) J. Med. Chem, 49, p. 709; Kaffy, J., Pontikis, R., Carrez, D., Croisy, A., Monneret, C., Florent, J.C., (2006) Bioorg Med. Chem, 27, p. 22",
year = "2008",
language = "English",
volume = "18",
pages = "87--88",
journal = "Indian Journal of Heterocyclic Chemistry",
issn = "0971-1627",
publisher = "National Academy of Chemistry",
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Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents. / Manna, K.; Agarwal, Y.K.; Srinivasan, K.K.

In: Indian Journal of Heterocyclic Chemistry, Vol. 18, No. 1, 2008, p. 87-88.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents

AU - Manna, K.

AU - Agarwal, Y.K.

AU - Srinivasan, K.K.

N1 - Cited By :4 Export Date: 10 November 2017 Correspondence Address: Manna, K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad, India References: Zboinska, E., Sztajer, H., Lejezak, B., Kafarski, P., (1990) FEMS Microbiol. Lett, 70, p. 23; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Rescifina, A., Chiacchio, M.A., Corsaro, A., De Clercq, E., lannazzo, D., Mastino, A., Piperno, A., Valveri, V., (2006) J. Med. Chem, 49, p. 709; Kaffy, J., Pontikis, R., Carrez, D., Croisy, A., Monneret, C., Florent, J.C., (2006) Bioorg Med. Chem, 27, p. 22

PY - 2008

Y1 - 2008

N2 - Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.

AB - Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.

M3 - Article

VL - 18

SP - 87

EP - 88

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

SN - 0971-1627

IS - 1

ER -