Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives

B. Chandrakantha, Arun M. Isloor, Prakash Shetty, Hoong Kun Fun, Gurumurthy Hegde

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2- yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)- 3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL.

Original languageEnglish
Pages (from-to)316-323
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume71
DOIs
Publication statusPublished - 07-01-2014

Fingerprint

Spectrum analysis
Nuclear magnetic resonance
Derivatives
Chemical analysis
1,3,4-thiadiazole
propionamide
imidazo(2,1-b)(1,3,4)thiadiazole

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

@article{b10737a8bfb84971951e435045ec477a,
title = "Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives",
abstract = "A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2- yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)- 3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL.",
author = "B. Chandrakantha and Isloor, {Arun M.} and Prakash Shetty and Fun, {Hoong Kun} and Gurumurthy Hegde",
year = "2014",
month = "1",
day = "7",
doi = "10.1016/j.ejmech.2013.10.056",
language = "English",
volume = "71",
pages = "316--323",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",

}

Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives. / Chandrakantha, B.; Isloor, Arun M.; Shetty, Prakash; Fun, Hoong Kun; Hegde, Gurumurthy.

In: European Journal of Medicinal Chemistry, Vol. 71, 07.01.2014, p. 316-323.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives

AU - Chandrakantha, B.

AU - Isloor, Arun M.

AU - Shetty, Prakash

AU - Fun, Hoong Kun

AU - Hegde, Gurumurthy

PY - 2014/1/7

Y1 - 2014/1/7

N2 - A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2- yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)- 3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL.

AB - A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2- yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)- 3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL.

UR - http://www.scopus.com/inward/record.url?scp=84889014805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889014805&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2013.10.056

DO - 10.1016/j.ejmech.2013.10.056

M3 - Article

C2 - 24321835

AN - SCOPUS:84889014805

VL - 71

SP - 316

EP - 323

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -