Synthesis and biological evaluation of some novel quinazolones

E. Jessy, A. Sambanthan, A. Joseph, C. Sridevi, K. Srinivasan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1- quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.
Original languageEnglish
Pages (from-to)476-478
Number of pages3
JournalIndian Journal of Pharmaceutical Sciences
Volume69
Issue number3
Publication statusPublished - 2007

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Anti-Inflammatory Agents
Ibuprofen
Ciprofloxacin
4-hydroxyquinazoline

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Jessy, E. ; Sambanthan, A. ; Joseph, A. ; Sridevi, C. ; Srinivasan, K. / Synthesis and biological evaluation of some novel quinazolones. In: Indian Journal of Pharmaceutical Sciences. 2007 ; Vol. 69, No. 3. pp. 476-478.
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title = "Synthesis and biological evaluation of some novel quinazolones",
abstract = "In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1- quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.",
author = "E. Jessy and A. Sambanthan and A. Joseph and C. Sridevi and K. Srinivasan",
note = "Cited By :15 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Jessy, E.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical SciencesIndia; email: jessyjamesmathew@yahoo.co.in Chemicals/CAS: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; ciprofloxacin, 85721-33-1; ibuprofen, 15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6 References: Srivastava, V.K., Singh, S., Gupti, A., Shankar, K., (1987) Indian. J. Chem, 26 B, p. 652; Agnihotri, A.K., Shukla, S.K., (1972) Arch. Pharm, 315, p. 701; Lemura, R., Manabe, H., Todayaki, S., (1989) Chem. Pharm. Bull, 37, p. 2723; Vanhouttle, R.M., (1985) J. Cardiovasc. Pharmacol, 7, p. 5105; Parmar, J.S., Singh, S.P., (1979) J, Heterocyclic. Chem, 16, p. 448; Joshi, V., Chaudhary, R.P., (1987) Indian J. Chem, 26 B, p. 602; Robba, M., Cagniant, S.M., Leucomte, J.M., (1975) J. Heterocyclic. Chem, 12, p. 525; Zentmyer, D.T., Wagner, E.C., (1948) J. Org. Chem, 14, p. 967; Winter, C.A., Risely, E.A., Nu, G.N., (1962) Proc. Soc. Exp. Biol, 111, p. 54719; Gillespie, S.H., (1994) Medical Microbiology-Illustrated, p. 1. , 1st edn, Butterworth Heinemann;",
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Jessy, E, Sambanthan, A, Joseph, A, Sridevi, C & Srinivasan, K 2007, 'Synthesis and biological evaluation of some novel quinazolones', Indian Journal of Pharmaceutical Sciences, vol. 69, no. 3, pp. 476-478.

Synthesis and biological evaluation of some novel quinazolones. / Jessy, E.; Sambanthan, A.; Joseph, A.; Sridevi, C.; Srinivasan, K.

In: Indian Journal of Pharmaceutical Sciences, Vol. 69, No. 3, 2007, p. 476-478.

Research output: Contribution to journalArticle

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AU - Sambanthan, A.

AU - Joseph, A.

AU - Sridevi, C.

AU - Srinivasan, K.

N1 - Cited By :15 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Jessy, E.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical SciencesIndia; email: jessyjamesmathew@yahoo.co.in Chemicals/CAS: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; ciprofloxacin, 85721-33-1; ibuprofen, 15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6 References: Srivastava, V.K., Singh, S., Gupti, A., Shankar, K., (1987) Indian. J. Chem, 26 B, p. 652; Agnihotri, A.K., Shukla, S.K., (1972) Arch. Pharm, 315, p. 701; Lemura, R., Manabe, H., Todayaki, S., (1989) Chem. Pharm. Bull, 37, p. 2723; Vanhouttle, R.M., (1985) J. Cardiovasc. Pharmacol, 7, p. 5105; Parmar, J.S., Singh, S.P., (1979) J, Heterocyclic. Chem, 16, p. 448; Joshi, V., Chaudhary, R.P., (1987) Indian J. Chem, 26 B, p. 602; Robba, M., Cagniant, S.M., Leucomte, J.M., (1975) J. Heterocyclic. Chem, 12, p. 525; Zentmyer, D.T., Wagner, E.C., (1948) J. Org. Chem, 14, p. 967; Winter, C.A., Risely, E.A., Nu, G.N., (1962) Proc. Soc. Exp. Biol, 111, p. 54719; Gillespie, S.H., (1994) Medical Microbiology-Illustrated, p. 1. , 1st edn, Butterworth Heinemann;

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N2 - In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1- quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.

AB - In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1- quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.

M3 - Article

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SP - 476

EP - 478

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

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