Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

V. Sumangala, Boja Poojary, N. Chidananda, T. Arulmoli, Shalini Shenoy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The basic nucleus 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2, 4]-triazole-3-thione was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by spectroscopic methods (IR, NMR, and Mass). In order to ascertain the pharmaceutical application, the selective pharmacological screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their cytotoxic activity and antimicrobial activity.

Original languageEnglish
Pages (from-to)2921-2928
Number of pages8
JournalMedicinal Chemistry Research
Volume22
Issue number6
DOIs
Publication statusPublished - 01-06-2013

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hydrazine
Thiones
Addition reactions
Schiff Bases
Cyclization
Aldehydes
Potassium
Screening
Ethanol
Nuclear magnetic resonance
Derivatives
Pharmaceutical Preparations
Pharmacology
1,2,4-triazole

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

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Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione. / Sumangala, V.; Poojary, Boja; Chidananda, N.; Arulmoli, T.; Shenoy, Shalini.

In: Medicinal Chemistry Research, Vol. 22, No. 6, 01.06.2013, p. 2921-2928.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

AU - Sumangala, V.

AU - Poojary, Boja

AU - Chidananda, N.

AU - Arulmoli, T.

AU - Shenoy, Shalini

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AB - The basic nucleus 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2, 4]-triazole-3-thione was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by spectroscopic methods (IR, NMR, and Mass). In order to ascertain the pharmaceutical application, the selective pharmacological screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their cytotoxic activity and antimicrobial activity.

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