Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.
|Number of pages||4|
|Journal||Indian Journal of Heterocyclic Chemistry|
|Publication status||Published - 2007|
Agarwal, Y. K., Manna, K., Bhatt, H., Gogai, P., Babu, V. H., & Srinivasan, K. K. (2007). Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents. Indian Journal of Heterocyclic Chemistry, 16(3), 263-266.