Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

Y.K. Agarwal, K. Manna, H. Bhatt, P. Gogai, V.H. Babu, K.K. Srinivasan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.
Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume16
Issue number3
Publication statusPublished - 2007
Externally publishedYes

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Acetaminophen
Anti-Infective Agents
Chalcones
Derivatives
Aldehydes
Condensation
Anti-Inflammatory Agents
1-benzofuran
benzofuran

Cite this

@article{44bf8492dd7f4b1cb34be7551d5b34cc,
title = "Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents",
abstract = "Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.",
author = "Y.K. Agarwal and K. Manna and H. Bhatt and P. Gogai and V.H. Babu and K.K. Srinivasan",
note = "Cited By :8 Export Date: 10 November 2017 Correspondence Address: Agarwal, Y.K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad-382 481, India References: Sangapure, S.S., Veeresh, H.D., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Kumar, N., Sharma, A.K., Garg, R., Yadav, A.K., (2006) Indian J. Chem, 45 B, p. 747; Bharmal, M.F., Kareriya, J.D., Parekh, H.H., (2001) Indian J. Heterocyclic Chem, 10, p. 181; Patel, R.B., Desai, P.S., Desai, R.K., Chikhalia, H.K., (2006) Indian J. Chem, 45 B, p. 773; Kumar, R., Prasad, V.V.S.R., Mayur, Y.C., Kumar, S.S.M., Raju, M.B., (2006) Indian J. Heterocyclic Chem, 15, p. 245",
year = "2007",
language = "English",
volume = "16",
pages = "263--266",
journal = "Indian Journal of Heterocyclic Chemistry",
issn = "0971-1627",
publisher = "National Academy of Chemistry",
number = "3",

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Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents. / Agarwal, Y.K.; Manna, K.; Bhatt, H.; Gogai, P.; Babu, V.H.; Srinivasan, K.K.

In: Indian Journal of Heterocyclic Chemistry, Vol. 16, No. 3, 2007, p. 263-266.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

AU - Agarwal, Y.K.

AU - Manna, K.

AU - Bhatt, H.

AU - Gogai, P.

AU - Babu, V.H.

AU - Srinivasan, K.K.

N1 - Cited By :8 Export Date: 10 November 2017 Correspondence Address: Agarwal, Y.K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad-382 481, India References: Sangapure, S.S., Veeresh, H.D., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Kumar, N., Sharma, A.K., Garg, R., Yadav, A.K., (2006) Indian J. Chem, 45 B, p. 747; Bharmal, M.F., Kareriya, J.D., Parekh, H.H., (2001) Indian J. Heterocyclic Chem, 10, p. 181; Patel, R.B., Desai, P.S., Desai, R.K., Chikhalia, H.K., (2006) Indian J. Chem, 45 B, p. 773; Kumar, R., Prasad, V.V.S.R., Mayur, Y.C., Kumar, S.S.M., Raju, M.B., (2006) Indian J. Heterocyclic Chem, 15, p. 245

PY - 2007

Y1 - 2007

N2 - Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.

AB - Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.

M3 - Article

VL - 16

SP - 263

EP - 266

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

SN - 0971-1627

IS - 3

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