Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

Y.K. Agarwal, K. Manna, H. Bhatt, P. Gogai, V.H. Babu, K.K. Srinivasan

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Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.
Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Issue number3
Publication statusPublished - 2007
Externally publishedYes


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