Synthesis and characterization of Schiff bases of 2′-amino-4′- (6-chloro-3-coumarinyl)thiazole as potential NSAIDs

B. S. Jayashree, D. Anuradha, K. N. Venugopala

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Some of the Schiff bases of aminothiazolylchlorocoumarin are synthesized by the reaction between 2′-amino-4′-(6-chloro-3-coumarinyl)thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-chlorocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for their analgesic and anti-inflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Few of the compounds have shown interesting biological activity based on the presence of certain functional groups.

Original languageEnglish
Pages (from-to)2093-2097
Number of pages5
JournalAsian Journal of Chemistry
Volume17
Issue number4
Publication statusPublished - 01-10-2005

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Thiazoles
Thiourea
Schiff Bases
Carrageenan
Cyclization
Non-Steroidal Anti-Inflammatory Agents
Bioactivity
Aldehydes
Acetic Acid
Functional groups
Rats

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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Synthesis and characterization of Schiff bases of 2′-amino-4′- (6-chloro-3-coumarinyl)thiazole as potential NSAIDs. / Jayashree, B. S.; Anuradha, D.; Venugopala, K. N.

In: Asian Journal of Chemistry, Vol. 17, No. 4, 01.10.2005, p. 2093-2097.

Research output: Contribution to journalArticle

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