Synthesis and characterization of Schiff bases of aminothiazolylbromo coumarin for their analgesic and anti-inflammatory activity

K. N. Venugopala, B. S. Jayashree

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Some of the Schiff bases of aminothiazolylbromocoumarin are synthesized by the reaction between 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-bromocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for analgesic and anti-inflammatory activity by acetic acid-induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Some of the compounds have shown interesting biological activity based on the presence of certain functional groups.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalAsian Journal of Chemistry
Issue number1
Publication statusPublished - 01-01-2004


All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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