Some of the Schiff bases of aminothiazolylbromocoumarin are synthesized by the reaction between 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-bromocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for analgesic and anti-inflammatory activity by acetic acid-induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Some of the compounds have shown interesting biological activity based on the presence of certain functional groups.
|Number of pages||5|
|Journal||Asian Journal of Chemistry|
|Publication status||Published - 01-01-2004|
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