Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

Mohammad Shahar Yar, Anees Ahmad Siddiqui, Mohamed Ashraf Ali, Vedigounder Murugan, Raghu Chandrashekhar

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13 Citations (Scopus)

Abstract

In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5-(4-flurophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro- 1H-1-pyrazolyl-2-toluidino methane thione & 5-(4-chlorophenyl)-3-(4-hydroxy- 3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalJournal of the Chinese Chemical Society
Volume54
Issue number1
DOIs
Publication statusPublished - 01-01-2007

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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